Transthyretin/Prealbumin Antibody (7B2)

Images

 
Western Blot: Transthyretin/Prealbumin Antibody (7B2) [NBP1-74022] - Mouse Liver lysates (35ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human TTR (1:3000). Proteins were visualized ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA
Clone
7B2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1 mg/ml

Transthyretin/Prealbumin Antibody (7B2) Summary

Immunogen
Recombinant human TTR (11-147aa) purified from E.coli
Specificity
Anti-human TTR mAb, clone 7B2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TTR protein.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TTR
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
Application Notes
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 3000. Recommended starting dilution is 1:500

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4) and 10% Glycerol
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Protein G purified

Alternate Names for Transthyretin/Prealbumin Antibody (7B2)

  • ATTR
  • HsT2651
  • PALB
  • PALBTBPA
  • Prealbumin
  • prealbumin, amyloidosis type I
  • TBPA
  • thyroxine-binding prealbumin
  • Transthyretin
  • TTR

Background

TTR encodes transthyretin, a circulating and abundant tetramer that functions as a carrier protein of thyroid hormone and retinol binding protein. Transthyretin(TTR) is mainly produced in the liver, but also in the brain and eye. Mutations in TTR cause the protein to dissociate into monomers that after misfolding assemble into amyloid fibrils deposits in a diversity of organs. TTR is also the only gene known to be associated with familial TTR amyloidosis. Familial transthyretin (TTR) amyloidosis is characterized by a slowly progressive peripheral sensorimotor neuropathy and autonomic neuropathy as well as non-neuropathic changes of cardiomyopathy, nephropathy, vitreous opacities, and CNS amyloidosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Transthyretin/Prealbumin Antibody (NBP1-74022). (Showing 1 - 1 of 1 FAQ).

  1. For my purposes it is important to find antibodies that are specific for a single Exon. The transthyretin protein is 147aa long (Exon 1 is aa 1-23 / Exon 2 is aa 24-67 / Exon 3 is aa 68-112 / Exon 4 is aa 113-147). Would it be possible to provide me with the amino acid sequence of the epitope for NBP1-74022?
    • NBP1-74022 is not epitope mapped. It is made to the full length protein.

Secondary Antibodies

 

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Bioinformatics

Gene Symbol TTR
Entrez
Uniprot