Transglutaminase 2/TGM2 Antibody (SPM592) [DyLight 350]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Pm, RbSpecies Glossary
Applications Flow, IHC, IHC-P
Clone
SPM592
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 350

Order Details

Transglutaminase 2/TGM2 Antibody (SPM592) [DyLight 350] Summary

Immunogen
Recombinant full-length human TGM2 protein
Localization
Cytoplasmic and cell surface
Specificity
Recognizes a 77-85kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TGM2
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Transglutaminase 2/TGM2 Antibody (SPM592) [DyLight 350]

  • C polypeptide
  • EC 2.3.2.13
  • G-ALPHA-h
  • protein-glutamine gamma-glutamyltransferase 2
  • protein-glutamine-gamma-glutamyltransferase
  • TG(C)
  • TG2
  • TGase C
  • TGase H
  • TGase-2
  • TGase-H
  • TGC
  • TGCGNAH
  • TGM2
  • Tissue transglutaminase
  • transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
  • Transglutaminase 2
  • Transglutaminase C
  • Transglutaminase H
  • transglutaminase-2
  • tTG

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-47927AF350
Alexa Fluor 405 NBP2-47927AF405
Alexa Fluor 488 NBP2-47927AF488
Alexa Fluor 532 NBP2-47927AF532
Alexa Fluor 594 NBP2-47927AF594
Alexa Fluor 647 NBP2-47927AF647
Alexa Fluor 700 NBP2-47927AF700
Alexa Fluor 750 NBP2-47927AF750
Allophycocyanin NBP2-47927APC
Allophycocyanin/Cy7 NBP2-47927APCCY7
Biotin NBP2-47927B
DyLight 350 NBP2-47927UV
DyLight 405 NBP2-47927V
DyLight 488 NBP2-47927G
DyLight 550 NBP2-47927R
DyLight 594 NBP2-47927DL594
DyLight 650 NBP2-47927C
DyLight 680 NBP2-47927FR
DyLight 755 NBP2-47927IR
FITC NBP2-47927F
HRP NBP2-47927H
Janelia Fluor 549 NBP2-47927JF549
Janelia Fluor 646 NBP2-47927JF646
PE NBP2-47927PE
PE/Atto594 NBP2-47927PEATT594
PE/Cy5.5 NBP2-47927PECY55
PE/Cy7 NBP2-47927PECY7
PerCP NBP2-47927PCP

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Bioinformatics

Gene Symbol TGM2