Transferrin Antibody Summary
Transferrin isolated from human serum.
This reacts with human transferrin. It stains hepatocytes in fetal liver, epithelial cells of colon adenocarcinoma and cells of normal liver.
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Frozen 1:10-1:500
- Immunohistochemistry-Paraffin 1:10-1:500
This antibody may be diluted to a titer of 1:50-1:100 in an ABC allmethod. We suggest an incubation period of 30-60 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation and dilutions should be determined by the user.
Cross-reacts with Human. Not yet tested in other species.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Alternate Names for Transferrin Antibody
- Beta-1 metal-binding globulin
- EC 3.4.21
Transferrin is a single polypeptide chain glycoprotein and is a member of the iron binding family of proteins. It has a molecular weight of 77 kDa and a serum concentration range of 1800 to 2700 mg/L. It is synthesised in the liver and consists of two domains each having a high affinity reversible binding site for Fe3+. The iron is transported in blood and interstitial fluids to sites of use and disposal. Iron/transferrin is essential in haemoglobin synthesis and for certain types of cell division. Serum concentration rises in iron deficiency and pregnancy and falls in iron overload, infection and inflammatory conditions.
The function of transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. In addition to its function in iron transport, this protein may also have a physiologic role as granulocyte/pollen binding protein (GPBP) involved in the removal of certain organic matter/allergins from serum.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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