Recombinant TRANCE/TNFSF11/RANK L Protein



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Recombinant TRANCE/TNFSF11/RANK L Protein Summary

A partial protein corresponding to TNFSF11.
E. coli expressed amino acid Lys158 - Asp316 (Accession # Q3TWY5).
Details of Functionality
The ED50, as measured by induction of osteoclast formation on mouse RAW264.7 cells, is 4.8 ng/ml.
Protein/Peptide Type
Partial Recombinant Protein
Endotoxin Note
Less than 0.01 ng/ug cytokine as determined by the LAL assay.


Application Notes
ED,50 as measured by induction of osteoclast formation on mouse RAW264.7 cells, is 4.8 ng/ml

Reactivity Notes

This protein was made to the human sequence.

Packaging, Storage & Formulations

Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid, phosphate buffered saline, pH 7.2, with 1.0% BSA. 0.22um filtered.
0.09% Sodium Azide
0.1 mg/ml


Purity: than 90%, as determined by reducing SDS-PAGE

Alternate Names for Recombinant TRANCE/TNFSF11/RANK L Protein

  • CD254 antigen
  • CD254
  • ODF
  • OPGL
  • Osteoclast differentiation factor
  • Osteoprotegerin ligand
  • RANK L
  • RANKLreceptor activator of nuclear factor kappa B ligand
  • Receptor activator of nuclear factor kappa-B ligand
  • sOdf
  • TNF-related activation-induced cytokine
  • TNFSF11
  • tumor necrosis factor (ligand) superfamily, member 11
  • tumor necrosis factor ligand superfamily member 11


RANK Ligand (Receptor Activator for Nuclear Factor kappaB Ligand), also known as TNF-related activation-induced cytokine (TRANCE), along with RANK are members of the TNF superfamily. RANK-L can be found as a soluble protein expressed by activated T lymphocytes, which plays a role in dendritic cell maturation. In addition it has also been shown to be cleaved by TACE (TNF-alpha convertase) releasing an ectodomain variant of the cell bound form. Lastly RANK-L is expressed as a Type II transmembrane protein expressed by osteoblast lineages. The receptor RANK, located on osteoclastic and dendritic cells can recognize all forms of RANK-L. RANK-L plays a critical role in bone development and mineralization. High levels of RANK-L have been associated with degenerative bone diseases.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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The diverse functions of RANKL/TRANCE/TNFSF11
RANKL (also known as TNF-related activation-induced cytokine), or receptor activator of nuclear factor-?B ligand, was first discovered as a key player in the RANKL/RANK/OPG osteoclast formation pathway. Osteoclasts are large multinucleate cells t...  Read full blog post.

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Gene Symbol TNFSF11