Recombinant TRANCE/TNFSF11/RANK L Protein

Images

 

Product Details

Summary
Product Discontinued
View other related TRANCE/TNFSF11/RANK L Peptides and Proteins

Order Details


    • Catalog Number
      NBP1-43167
    • Availability
      Product Discontinued

    Can't find what you are looking for? Use our Antibody Concierge Service & we will help you locate your antibody!

    Or feel free to contact us for alternative products.

Recombinant TRANCE/TNFSF11/RANK L Protein Summary

Description
A partial protein corresponding to TNFSF11.
Preparation
Method
E. coli expressed amino acid Lys158 - Asp316 (Accession # Q3TWY5).
Details of Functionality
The ED50, as measured by induction of osteoclast formation on mouse RAW264.7 cells, is 4.8 ng/ml.
Protein/Peptide Type
Partial Recombinant Protein
Gene
TNFSF11
Endotoxin Note
Less than 0.01 ng/ug cytokine as determined by the LAL assay.

Applications/Dilutions

Application Notes
ED,50 as measured by induction of osteoclast formation on mouse RAW264.7 cells, is 4.8 ng/ml

Reactivity Notes

This protein was made to the human sequence.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
Sterile liquid, phosphate buffered saline, pH 7.2, with 1.0% BSA. 0.22um filtered.
Preservative
0.09% Sodium Azide
Concentration
0.1 mg/ml

Notes

Purity: than 90%, as determined by reducing SDS-PAGE

Alternate Names for Recombinant TRANCE/TNFSF11/RANK L Protein

  • CD254 antigen
  • CD254
  • ODF
  • OPGL
  • OPGLOPTB2
  • Osteoclast differentiation factor
  • Osteoprotegerin ligand
  • RANK L
  • RANKL
  • RANKLreceptor activator of nuclear factor kappa B ligand
  • Receptor activator of nuclear factor kappa-B ligand
  • sOdf
  • TNF-related activation-induced cytokine
  • TNFSF11
  • TRANCE
  • TRANCEODFhRANKL2
  • tumor necrosis factor (ligand) superfamily, member 11
  • tumor necrosis factor ligand superfamily member 11

Background

RANK Ligand (Receptor Activator for Nuclear Factor kappaB Ligand), also known as TNF-related activation-induced cytokine (TRANCE), along with RANK are members of the TNF superfamily. RANK-L can be found as a soluble protein expressed by activated T lymphocytes, which plays a role in dendritic cell maturation. In addition it has also been shown to be cleaved by TACE (TNF-alpha convertase) releasing an ectodomain variant of the cell bound form. Lastly RANK-L is expressed as a Type II transmembrane protein expressed by osteoblast lineages. The receptor RANK, located on osteoclastic and dendritic cells can recognize all forms of RANK-L. RANK-L plays a critical role in bone development and mineralization. High levels of RANK-L have been associated with degenerative bone diseases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Customers Who Viewed This Item Also Viewed...

NB100-56508
Species: Hu, Mu, Rt
Applications: WB, Flow, IHC, IHC-P, CyTOF-ready, Flow-CS
NB100-56505
Species: Hu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, CyTOF-ready
NB100-56715
Species: Hu
Applications: WB, IHC, IHC-P
MAB1419
Species: Hu, Rt
Applications: IHC, CyTOF-ready, ICC, ICFlow
NBP2-45293
Species: Hu, Mu, Rt
Applications: Flow, IHC, IHC-P, PAGE, IF
H00057410-M02
Species: Hu, Mu, Rt
Applications: WB, ELISA
NBP1-87315
Species: Hu
Applications: IHC, IHC-P
NBP2-35213
Species: Hu
H00001513-M01
Species: Hu
Applications: WB, ELISA, IHC-P
NBP2-29323
Species: Hu, Mu, Rt, Bv, Ca, Ch, Xp
NB100-56732
Species: Hu, Mu
Applications: WB, Simple Western, ICC/IF
NBP2-50037
Species: Hu, Mu, Rt, Po, Bv, Eq
Applications: WB, ICC/IF
NB300-164
Species: Hu, Po, Ca, Rt(-)
Applications: WB, ICC/IF, IHC-Fr, IHC-P, IP

Publications for TRANCE/TNFSF11/RANK L Protein (NBP1-43167) (0)

There are no publications for TRANCE/TNFSF11/RANK L Protein (NBP1-43167).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for TRANCE/TNFSF11/RANK L Protein (NBP1-43167) (0)

There are no reviews for TRANCE/TNFSF11/RANK L Protein (NBP1-43167). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

FAQs for TRANCE/TNFSF11/RANK L Protein (NBP1-43167) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Additional TRANCE/TNFSF11/RANK L Products

Bioinformatics Tool for TRANCE/TNFSF11/RANK L Protein (NBP1-43167)

Discover related pathways, diseases and genes to TRANCE/TNFSF11/RANK L Protein (NBP1-43167). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for TRANCE/TNFSF11/RANK L Protein (NBP1-43167)

Discover more about diseases related to TRANCE/TNFSF11/RANK L Protein (NBP1-43167).
 

Pathways for TRANCE/TNFSF11/RANK L Protein (NBP1-43167)

View related products by pathway.

PTMs for TRANCE/TNFSF11/RANK L Protein (NBP1-43167)

Learn more about PTMs related to TRANCE/TNFSF11/RANK L Protein (NBP1-43167).
 

Research Areas for TRANCE/TNFSF11/RANK L Protein (NBP1-43167)

Find related products by research area.

Blogs on TRANCE/TNFSF11/RANK L.

The diverse functions of RANKL/TRANCE/TNFSF11
RANKL (also known as TNF-related activation-induced cytokine), or receptor activator of nuclear factor-?B ligand, was first discovered as a key player in the RANKL/RANK/OPG osteoclast formation pathway. Osteoclasts are large multinucleate cells t...  Read full blog post.

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Recombinant TRANCE/TNFSF11/RANK L Protein and receive a gift card or discount.

Bioinformatics

Gene Symbol TNFSF11
Entrez