TRANCE/TNFSF11/RANK L Antibody (IK22/5) [Biotin]

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Flow Cytometry: TRANCE/TNFSF11/RANK L Antibody (IK22/5) [Biotin] [NBP1-43515] - Staining of 3-day unstimulated (left) and 3-day ConA activated (right) BALB/c splenocytes with 0.125 ug of Biotin Rat IgG2a Isotype Control ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-43515
    • Availability
      Product Discontinued

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TRANCE/TNFSF11/RANK L Antibody (IK22/5) [Biotin] Summary

Immunogen
NSO-derived recombinant mouse TRANCE
Specificity
TRANCE (IK22/5)
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Rat
Gene
TNFSF11
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
Application Notes
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric analysis, the suggested use of this reagent is: 0.5 microgram per one millioncells in 100 microliter volume. It is recommended that the reagent be titrated for optimal performance for each application.
Readout System

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
Preservative
0.09% Sodium Azide
Concentration
0.2 mg/ml
Purity
Protein A or G purified

Alternate Names for TRANCE/TNFSF11/RANK L Antibody (IK22/5) [Biotin]

  • CD254 antigen
  • CD254
  • ODF
  • OPGL
  • OPGLOPTB2
  • Osteoclast differentiation factor
  • Osteoprotegerin ligand
  • RANK L
  • RANKL
  • RANKLreceptor activator of nuclear factor kappa B ligand
  • Receptor activator of nuclear factor kappa-B ligand
  • sOdf
  • TNF-related activation-induced cytokine
  • TNFSF11
  • TRANCE
  • TRANCEODFhRANKL2
  • tumor necrosis factor (ligand) superfamily, member 11
  • tumor necrosis factor ligand superfamily member 11

Background

The IK22/5 monoclonal antibody reacts with mouse TRANCE (TNF-related activation-induced cytokine receptor) also known as RANKL (receptor activator of NF-kappaB ligand) and OPGL (Osteoprotegerin Ligand). TRANCE is a type II membrane protein with predicted molecular weight of 35 kDa. Its extracellular domain is most closely related to TRAIL, FasL and TNF. TRANCE mRNA is upregulated by TCR stimulation and is expressed abundantly by mouse T cells not B cells in mouse thymus and lymph nodes. TRANCE-deficient mouse lacks osteoclasts. In addition, TRANCE has been shown to be involved in the interactions between T-dendritic and T-B cells. It was also found to be critical in osteoclast differentiation. The TRANCE-RANK interaction regulates the expression of the anti-apoptotic molecule Bcl-xL.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Additional TRANCE/TNFSF11/RANK L Products

Bioinformatics Tool for TRANCE/TNFSF11/RANK L Antibody (NBP1-43515)

Discover related pathways, diseases and genes to TRANCE/TNFSF11/RANK L Antibody (NBP1-43515). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for TRANCE/TNFSF11/RANK L Antibody (NBP1-43515)

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Pathways for TRANCE/TNFSF11/RANK L Antibody (NBP1-43515)

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PTMs for TRANCE/TNFSF11/RANK L Antibody (NBP1-43515)

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Research Areas for TRANCE/TNFSF11/RANK L Antibody (NBP1-43515)

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Blogs on TRANCE/TNFSF11/RANK L.

The diverse functions of RANKL/TRANCE/TNFSF11
RANKL (also known as TNF-related activation-induced cytokine), or receptor activator of nuclear factor-?B ligand, was first discovered as a key player in the RANKL/RANK/OPG osteoclast formation pathway. Osteoclasts are large multinucleate cells t...  Read full blog post.

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Bioinformatics

Gene Symbol TNFSF11
Entrez