TRAIL R4/TNFRSF10D/DcR2 Antibody

Images

 
Western Blot: TRAIL R4/TNFRSF10D/DcR2 Antibody [NBP1-76985] - Analysis of 50 ug of whole cell lysate from HeLa cells with anti-DcR2 at 1:1000 dilution.
Immunocytochemistry/ Immunofluorescence: TRAIL R4/TNFRSF10D/DcR2 Antibody [NBP1-76985] - Analysis of DcR2 in mouse kidney tissue withDcR2 antibody at 20 ug/ml.
Immunohistochemistry: TRAIL R4/TNFRSF10D/DcR2 Antibody [NBP1-76985] - Analysis of DcR2 in mouse kidney node tissue with DcR2 antibody at 2.5 ug/ml.
Immunocytochemistry/ Immunofluorescence: TRAIL R4/TNFRSF10D/DcR2 Antibody [NBP1-76985] - Staining of HeLa cells using DcR2 antibody at 10ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

TRAIL R4/TNFRSF10D/DcR2 Antibody Summary

Immunogen
Antibody was raised against a 15 amino acid peptide near the center of human DcR2. The immunogen is located within amino acids 230 - 280 of DcR2.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TNFRSF10D
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
DcR2 antibody can be used for detection of DcR2 expression by Western blot at 1:1000 to 1:2000 dilution.
Theoretical MW
36 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
TRAIL R4/TNFRSF10D/DcR2 Peptide (NBP1-76985PEP)
Publications
Read Publications using
NBP1-76985 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TRAIL R4/TNFRSF10D/DcR2 Antibody

  • CD264 antigen
  • CD264
  • DcR2
  • DCR2decoy with truncated death domain
  • Decoy receptor 2
  • TNF receptor-related receptor for TRAIL
  • TNF-related apoptosis-inducing ligand receptor 4
  • TNFRSF10D
  • TRAIL R4
  • TRAILR4
  • TRAIL-R4
  • TRAILR4TRAIL receptor 4
  • TRUNDDTRAIL receptor with a truncated death domain
  • tumor necrosis factor receptor superfamily member 10D
  • tumor necrosis factor receptor superfamily, member 10d, decoy with truncateddeath domain

Background

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TRAIL R4/TNFRSF10D/DcR2 Antibody (NBP1-76985)(19)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Flow, Flow-CS, WB.


Filter By Application
Flow
(1)
Flow-CS
(1)
WB
(7)
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Filter By Species
Human
(6)
All Species
Showing Publications 1 - 10 of 19. Show All 19 Publications.
Publications using NBP1-76985 Applications Species
Gupta SC, Francis SK, Nair MS et al. Azadirone, a Limonoid Tetranortriterpene, Induces Death Receptors and Sensitizes Human Cancer Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) through a p53 Protein-independent Mechanism: EVIDENCE FOR THE ROLE OF THE ROS-ERK-CHOP-DEATH RECEPTOR PATHWAY. J Biol Chem 2013 Nov 8 [PMID: 24078627] (WB, Human) WB Human
Allen JE, Ferrini R, Dicker DT et al. Targeting TRAIL death receptor 4 with trivalent DR4 Atrimer complexes. Mol Cancer Ther. 2012 Oct [PMID: 22802267]

Details:
Antibodies cited: 1. DR5 (IMG-120A): Flow (cell surface) 2. DR4 (IMG-141): Flow (cell surface, HCT116 cells), Supplementary Fig. 5. 3. DcR2 (IMG-121-1): WB (SW620 and HCT15 cells), Supplementary Fig. 4.
Nagane M, Shimizu S, Mori E et al. Predominant antitumor effects by fully human anti-TRAIL-receptor 2 (DR5) monoclonal antibodies in human glioma cells in vitro and in vivo. Neuro Oncol. 2010 Jul [PMID: 20511188] (WB, Human)

Details:
Products cited: 1. DcR2 (IMG-121-1): WB (human glioma cell lines), Fig 4B. 2. DcR1 (IMG-245-1): WB (human glioma cell lines), Fig 4B.
WB Human
Taniguchi H, Yoshida T, Horinaka M et al. Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells. Cancer Res. 2008 Nov 1 [PMID: 18974136] (WB)

Details:
Products cited: 1. IMG-121 (DcR2): WB (human colon carcinoma SW480 cell line), Fig 3. 2. IMG-245 (DcR1): WB (human colon carcinoma SW480 cell line), Fig 3.
WB
Lunghi P, Giuliani N, Mazzera L et al. Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways. Blood. 2008 Sep 15 [PMID: 18583568] (WB, Human)

Details:
1. p73 (IMG-246): WB (human myeloma cell lines (HMCLs) XG-6 and XG-1), Fig. 4Ci. 2. p73 (deltaNp73) [IMG-313A]: WB (HMCLs), Fig. 4Ai. 3. DcR2 (IMG-121): WB (HMCLs), Fig. 5A.
WB Human
Zhang HY, Wang HQ, Liu HM et al. Regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by DJ-1 in thyroid cancer cells. Endocr Relat Cancer. 2008 Jun [PMID: 18430896] (WB, Human)

Details:
WB (human thyroid cells).
WB Human
Kawakubo T, Okamoto K, Iwata J et al. Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface. Cancer Res. 2007 Nov 15 [PMID: 18006832] (WB)

Details:
Products cited: 1. IMG-121 (DcR2): WB (human prostate carcinoma cell lines), Fig. 4B. 2. IMG-245 (DcR1): WB (human prostate carcinoma cell lines), Fig. 4B.
WB
Liu X, Yue P, Khuri FR, Sun SY. Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity. Cancer Res. 2005 Oct 15 [PMID: 16230375]
Poulaki V, Mitsiades CS, McMullan C et al. Human retinoblastoma cells are resistant to apoptosis induced by death receptors: role of caspase-8 gene silencing. Invest Ophthalmol Vis Sci. 2005 Jan [PMID: 15623796]
Fan QL, Zou WY, Song LH et al. Synergistic antitumor activity of TRAIL combined with chemotherapeutic agents in A549 cell lines in vitro and in vivo. Cancer Chemother Pharmacol. 2005 Feb [PMID: 15290100]
Show All 19 Publications.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for TRAIL R4/TNFRSF10D/DcR2 Antibody (NBP1-76985) (0)

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol TNFRSF10D
Entrez
Uniprot