TRAIL R3/TNFRSF10C Antibody (TRAIL-R3-02) [PE]

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-45026
    • Availability
      Product Discontinued

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TRAIL R3/TNFRSF10C Antibody (TRAIL-R3-02) [PE] Summary

Immunogen
TRAIL-R3 (aa 1-280) - hIgGhc fusion protein
Specificity
The TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TNFRSF10C
Purity
Protein A purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS and 0.2% (w/v) high grade BSA (protease free)
Preservative
15mM Sodium Azide
Concentration
0.1 mg/ml
Purity
Protein A purified

Notes

Store in the dark. Avoid prolonged exposure to light.

Alternate Names for TRAIL R3/TNFRSF10C Antibody (TRAIL-R3-02) [PE]

  • Antagonist decoy receptor for TRAIL/Apo-2L
  • CD263 antigen
  • CD263
  • cytotoxic TRAIL receptor-3
  • DcR1
  • DCR1MGC149502
  • Decoy receptor 1
  • Decoy TRAIL receptor without death domain
  • LITMGC149501
  • Lymphocyte inhibitor of TRAIL
  • TNFRSF10C
  • TRAIL R3
  • TRAIL receptor 3
  • TRAIL receptor without an intracellular domain
  • TRAILR3
  • TRAIL-R3
  • TRAILR3TNF-related apoptosis-inducing ligand receptor 3
  • TRIDDCR1-TNFR
  • tumor necrosis factor receptor superfamily member 10C
  • tumor necrosis factor receptor superfamily, member 10c, decoy without anintracellular domain

Background

The DJR3 monoclonal antibody reacts with human Decoy receptor 1 (DcR1), a glycophospholipid-anchored cell surface protein also known as TRAIL-R3, TRID, and LIT. DcR1 has an extracellular TRAIL binding domain and lacks the cytoplasmic death domain (DD) shared by several members of the TNF receptor superfamily. DcR1, along with DcR2, protects cells from TRAIL-mediated cytotoxicity. DcR1 binds to TRAIL and inhibits binding of TRAIL to DR4 or DR5. DcR1 is expressed broadly in many normal tissues at low level, but not in most tumors. Overexpression of DcR1 attenuates TRAIL-induced apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol TNFRSF10C
Entrez