TRAIL R2/TNFRSF10B Antibody

Images

 
Western Blot: TRAIL R2/TNFRSF10B Antibody [NBP1-76986] - Analysis of DR5/TRAIL-R2 in HeLa (H) and K562 (K) cell lysates with DR5 antibody at 2 ug/mL.
Immunocytochemistry/ Immunofluorescence: TRAIL R2/TNFRSF10B Antibody [NBP1-76986] - HeLa cells.
Immunocytochemistry/ Immunofluorescence: TRAIL R2/TNFRSF10B Antibody [NBP1-76986] - Analysis of DR5 in formalin-fixed HeLa cells using NBP1-76986 at 5 ug/ml.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

TRAIL R2/TNFRSF10B Antibody Summary

Immunogen
Antibody was raised against a peptide corresponding to 20 amino acids near the carboxy terminus of human DR5 precursor. The immunogen is located within the last 50 amino acids of DR5.
Specificity
Antibody has no cross reaction to DR4.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TNFRSF10B
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
Application Notes
DR5 antibody can be used for detection of DR5 expression by Western blot at 1:250 to 1:500 dilution. antibody has no cross reaction to DR4.
Control Peptide
TRAIL R2/TNFRSF10B Peptide (NBP1-76986PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TRAIL R2/TNFRSF10B Antibody

  • CD262 antigen
  • CD262
  • death domain containing receptor for TRAIL/Apo-2L
  • Death receptor 5
  • DR5
  • DR5TRICK2B
  • Fas-like protein
  • KILLER/DR5
  • KILLERapoptosis inducing protein TRICK2A/2B
  • TNF-related apoptosis-inducing ligand receptor 2
  • TNFRSF10B
  • TRAIL R2
  • TRAIL receptor 2
  • TRAILR2
  • TRAIL-R2apoptosis inducing receptor TRAIL-R2
  • TRAILR2cytotoxic TRAIL receptor-2
  • TRICK2
  • TRICK2A
  • TRICKB
  • tumor necrosis factor receptor superfamily member 10B
  • tumor necrosis factor receptor superfamily, member 10b
  • tumor necrosis factor receptor-like protein ZTNFR9
  • ZTNFR9

Background

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kappaB.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol TNFRSF10B
Entrez
Uniprot