TRAIL R2/TNFRSF10B Antibody (45B872.1)

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Western Blot: TRAIL-R2 Antibody (45B872.1) [NB100-56673] - Western blot analysis of 50 ug of whole cell lysate from HeLa cells with anti-DR5 at 1:1000 dilution.

Product Details

Summary
Product Discontinued
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    • Catalog Number
      NB100-56673
    • Availability
      Product Discontinued

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TRAIL R2/TNFRSF10B Antibody (45B872.1) Summary

Immunogen
This monoclonal antibody was raised against a peptide corresponding to amino acids 142 to 155 of human DR5 precursor (6,7).
Specificity
DR5 (45B872.1)
Isotype
IgM
Clonality
Monoclonal
Host
Mouse
Gene
TNFRSF10B
Purity
Unpurified
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Applications/Dilutions

Reactivity Notes

Cross reacts with Human and Mouse. Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Ascites with PBS and 0.2% Gelatin
Preservative
0.05% Sodium Azide
Purity
Unpurified

Alternate Names for TRAIL R2/TNFRSF10B Antibody (45B872.1)

  • CD262 antigen
  • CD262
  • death domain containing receptor for TRAIL/Apo-2L
  • Death receptor 5
  • DR5
  • DR5TRICK2B
  • Fas-like protein
  • KILLER/DR5
  • KILLERapoptosis inducing protein TRICK2A/2B
  • TNF-related apoptosis-inducing ligand receptor 2
  • TNFRSF10B
  • TRAIL R2
  • TRAIL receptor 2
  • TRAILR2
  • TRAIL-R2apoptosis inducing receptor TRAIL-R2
  • TRAILR2cytotoxic TRAIL receptor-2
  • TRICK2
  • TRICK2A
  • TRICKB
  • tumor necrosis factor receptor superfamily member 10B
  • tumor necrosis factor receptor superfamily, member 10b
  • tumor necrosis factor receptor-like protein ZTNFR9
  • ZTNFR9

Background

Cells undergo programmed cell death (Apoptosis) in response to various stimuli. Apoptosis is essential for morphogenesis, tissue homeostasis, and host defense1. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently2-8. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TRAIL R2/TNFRSF10B Antibody (NB100-56673)(1)

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Bioinformatics

Gene Symbol TNFRSF10B
Entrez