Cross reacts with Human and Mouse. Not yet tested in other species.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Ascites with PBS and 0.2% Gelatin
0.05% Sodium Azide
Alternate Names for TRAIL R2/TNFRSF10B Antibody (45B872.1)
death domain containing receptor for TRAIL/Apo-2L
Death receptor 5
KILLERapoptosis inducing protein TRICK2A/2B
TNF-related apoptosis-inducing ligand receptor 2
TRAIL receptor 2
TRAIL-R2apoptosis inducing receptor TRAIL-R2
TRAILR2cytotoxic TRAIL receptor-2
tumor necrosis factor receptor superfamily member 10B
tumor necrosis factor receptor superfamily, member 10b
tumor necrosis factor receptor-like protein ZTNFR9
Cells undergo programmed cell death (Apoptosis) in response to various stimuli. Apoptosis is essential for morphogenesis, tissue homeostasis, and host defense1. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently2-8. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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