TRAIL R1/TNFRSF10A Antibody (DR-4-02) - Azide Free

Images

 
Flow Cytometry: TRAIL R1/TNFRSF10A Antibody (DR-4-02) - Azide Free [NBP2-31343] - Using the PE direct conjugate Surface staining of CD261-transfected HEK-293 cells with anti-CD261/TRAIL-R1 (DR-4-02) PE.
Immunofluorescence: TRAIL R1/TNFRSF10A Antibody (DR-4-02) - Azide Free [NBP2-31343] - Staining (confocal microscopy) of HeLa human cervix carcinoma cell line transfected with TRAIL-R1 expression plasmid using anti-human ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, Func, ICC/IF, IP, CyTOF-ready, IF
Clone
DR-4-02
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Format
Azide Free
Concentration
1.0 mg/ml

TRAIL R1/TNFRSF10A Antibody (DR-4-02) - Azide Free Summary

Immunogen
Fusion protein (Human). Fusion protein containing the extracellular part of DR4 and the constant part of the heavy chain of the human IgG1 (NM_003844.3).
Localization
Cell Membrane
Specificity
DR4 (DR-4-02)
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TNFRSF10A
Purity
Protein A purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Flow Cytometry 3 - 5ug/ml
  • Functional
  • Immunocytochemistry/Immunofluorescence
  • Immunoprecipitation
  • CyTOF-ready
  • Immunofluorescence
Application Notes
Soluble antibody DR-4-02 blocks apoptosis triggered by a ligand (TRAIL). Plastic-immobilized (cross-linked) DR-4-02 antibody induces apoptosis in sensitive cells. Recommended dilution of antibody: 2-3 ug/ml in cultivation medium Final concentration of TRAIL: 20-200 ng/ml It is recommended to add the antibody 15 min before addition of TRAIL.
Publications
Read Publications using NBP2-31343.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (approx. pH 7.0)
Preservative
No Preservative
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for TRAIL R1/TNFRSF10A Antibody (DR-4-02) - Azide Free

  • APO2
  • CD261 antigen
  • CD261
  • cytotoxic TRAIL receptor
  • Death receptor 4
  • DR4 TRAIL receptor 1
  • DR4
  • TNF-related apoptosis inducing ligand receptor 1
  • TNF-related apoptosis-inducing ligand receptor 1
  • TNFRSF10A
  • TRAIL R1
  • TRAILR1
  • TRAIL-R1
  • TRAILR-1
  • TRAILR1MGC9365
  • tumor necrosis factor receptor superfamily member 10A
  • tumor necrosis factor receptor superfamily, member 10a

Background

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor 1(TRAIL R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF kB activation in many tissues and cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TRAIL R1/TNFRSF10A Antibody (NBP2-31343)(2)


Showing Publications 1 - 2 of 2.
Publications using NBP2-31343 Applications Species
Sarkar S, Faller DV. Telomere-Homologous G-Rich Oligonucleotides Sensitize Human Ovarian Cancer Cells to TRAIL-Induced Growth Inhibition and Apoptosis Nucleic Acid Ther 2013 May 2 2013 May 2 [PMID: 23634944]

Details:
This citation used the FITC version of this antibody.
Sarkar S, Faller DV. Telomere-Homologous G-Rich Oligonucleotides Sensitize Human Ovarian Cancer Cells to TRAIL-Induced Growth Inhibition and Apoptosis Nucleic Acid Ther 2013 May 2

Details:
This publication used the FITC conjugated form of this antibody (Cat# NB110-81756).

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol TNFRSF10A
Entrez