TRAIL R1/TNFRSF10A Antibody (DR-4-02) - Azide Free Summary
Fusion protein (Human). Fusion protein containing the extracellular part of DR4 and the constant part of the heavy chain of the human IgG1 (NM_003844.3).
Protein A purified
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Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Phosphate buffered saline (PBS), approx. pH 7.4
Protein A purified
Soluble antibody DR-4-02 blocks apoptosis triggered by a ligand (TRAIL). Plastic-immobilized (cross-linked) DR-4-02 antibody induces apoptosis in sensitive cells. Recommended dilution of antibody: 2-3 ug/ml in cultivation medium Final concentration of TRAIL: 20-200 ng/ml It is recommended to add the antibody 15 min before addition of TRAIL.
Alternate Names for TRAIL R1/TNFRSF10A Antibody (DR-4-02) - Azide Free
- CD261 antigen
- cytotoxic TRAIL receptor
- Death receptor 4
- DR4 TRAIL receptor 1
- TNF-related apoptosis inducing ligand receptor 1
- TNF-related apoptosis-inducing ligand receptor 1
- tumor necrosis factor receptor superfamily member 10A
- tumor necrosis factor receptor superfamily, member 10a
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor 1(TRAIL R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF kB activation in many tissues and cells.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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Publications for TRAIL R1/TNFRSF10A Antibody (NBP2-31343)(1)
Showing Publication 1 - 1
|Publication using NBP2-31343
|Sarkar S, Faller DV. Telomere-Homologous G-Rich Oligonucleotides Sensitize Human Ovarian Cancer Cells to TRAIL-Induced Growth Inhibition and Apoptosis Nucleic Acid Ther 2013 May 2
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