Western Blot: TRAIL R1/TNFRSF10A Antibody (32A242) [NB100-56528] - Analysis of 20 ug of total cell lysate from HeLa cells with DR4 antibody at 2 ug/ml. Goat anti-mouse Ig HRP secondary antibody and PicoTect ECL ...read more
Western Blot: TRAIL R1/TNFRSF10A Antibody (32A242) [NB100-56528] - Analysis using Azide/BSA FREE version of NB100-56528. Analysis of 20 ug of total cell lysate from HeLa cells with DR4 antibody at 2 ug/ml. Goat ...read more
Alternate Names for TRAIL R1/TNFRSF10A Antibody (32A242)
cytotoxic TRAIL receptor
Death receptor 4
DR4 TRAIL receptor 1
TNF-related apoptosis inducing ligand receptor 1
TNF-related apoptosis-inducing ligand receptor 1
tumor necrosis factor receptor superfamily member 10A
tumor necrosis factor receptor superfamily, member 10a
Cells undergo programmed cell death (Apoptosis) in response to various stimuli. Apoptosis is essential for morphogenesis, tissue homeostasis, and host defense. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.