TRAIL R1/TNFRSF10A Antibody (32A242)


Western Blot: TRAIL R1/TNFRSF10A Antibody (32A242) [NB100-56528] - Analysis of 20 ug of total cell lysate from HeLa cells with DR4 antibody at 2 ug/ml. Goat anti-mouse Ig HRP secondary antibody and PicoTect ECL more
Western Blot: TRAIL R1/TNFRSF10A Antibody (32A242) [NB100-56528] - Analysis using Azide/BSA FREE version of NB100-56528. Analysis of 20 ug of total cell lysate from HeLa cells with DR4 antibody at 2 ug/ml. Goat more

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF
0.5 mg/ml

TRAIL R1/TNFRSF10A Antibody (32A242) Summary

This monoclonal antibody was raised against a peptide corresponding to amino acid 2 to 21 of human DR4.
In HeLa, a 57 kDa band should be observed.
Protein G purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS containing 0.05% BSA
0.05% Sodium Azide
0.5 mg/ml
Protein G purified


Application Notes
Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID 23988408)
Read Publications using
NB100-56528 in the following applications:

Alternate Names for TRAIL R1/TNFRSF10A Antibody (32A242)

  • APO2
  • CD261 antigen
  • CD261
  • cytotoxic TRAIL receptor
  • Death receptor 4
  • DR4 TRAIL receptor 1
  • DR4
  • TNF-related apoptosis inducing ligand receptor 1
  • TNF-related apoptosis-inducing ligand receptor 1
  • TRAIL-R1
  • TRAILR-1
  • TRAILR1MGC9365
  • tumor necrosis factor receptor superfamily member 10A
  • tumor necrosis factor receptor superfamily, member 10a


Cells undergo programmed cell death (Apoptosis) in response to various stimuli. Apoptosis is essential for morphogenesis, tissue homeostasis, and host defense. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TRAIL R1/TNFRSF10A Antibody (NB100-56528)(7)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, WB.

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Showing Publications 1 - 7 of 7.
Publications using NB100-56528 Applications Species
Wen Q, Wang W, Luo J et al. CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway. Oncotarget. Mar 30 2016 12:00AM [PMID:27050281] (WB, Human) WB Human
Di Xu, Zhang Guofeng, Zhang Yaqin et al. Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5. Oncotarget. 2013 Sep [PMID:23988408] (ICC/IF) ICC/IF
Brooks AD, Jacobsen KM, Li W et al. Bortezomib sensitizes human renal cell carcinomas to TRAIL apoptosis through increased activation of caspase-8 in the death-inducing signaling complex. Mol Cancer Res. 2010 May [PMID:20442297]
Laguinge LM, Samara RN, Wang W et al. DR5 receptor mediates anoikis in human colorectal carcinoma cell lines. Cancer Res. 2008 Feb 1 [PMID:18245494]
Xu J, Zhou JY, Wu GS. Tumor necrosis factor-related apoptosis-inducing ligand is required for tumor necrosis factor alpha-mediated sensitization of human breast cancer cells to chemotherapy. Cancer Res. 2006 Oct 15 [PMID:17047073]
Cisternas P, Moreno RD. Comparative analysis of apoptotic pathways in rat, mouse, and hamster spermatozoa. Mol Reprod Dev. 2006 Oct [PMID:16868928] (WB) WB
Jin F, Liu X, Zhou Z et al. Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Res. 2005 Jul 15 [PMID:16024638] (WB) WB

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for TRAIL R1/TNFRSF10A Antibody (NB100-56528) (0)

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NB100-56528AF405
Alexa Fluor (R) 488 Labeled NB100-56528AF488
Alexa Fluor (R) 647 Labeled NB100-56528AF647
Alexa Fluor (R) 700 Labeled NB100-56528AF700
Allophycocyanin Labeled NB100-56528APC
Biotin Labeled NB100-56528B
DyLight 350 Labeled NB100-56528UV
DyLight 405 Labeled NB100-56528V
DyLight 405LS Labeled NB100-56528V3
DyLight 488 Labeled NB100-56528G
DyLight 550 Labeled NB100-56528R
DyLight 650 Labeled NB100-56528C
DyLight 680 Labeled NB100-56528FR
DyLight 755 Labeled NB100-56528IR
HRP Labeled NB100-56528H
PE Labeled NB100-56528PE
PerCP Labeled NB100-56528PCP

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Contact Information

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Gene Symbol TNFRSF10A

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