TRAF-2 Antibody

Images

 
Western Blot: TRAF-2 Antibody [NBP1-77247] - Analysis of TRAF2 in mouse liver tissue lysate with TRAF2 antibody at 1 ug/mL.
Immunohistochemistry-Paraffin: TRAF-2 Antibody [NBP1-77247] - Mouse liver tissue with TRAF2 antibody at 10 ug/mL.
Western Blot: TRAF-2 Antibody [NBP1-77247] - Mouse liver tissue lysate with TRAF2 antibody at (A) 0.5, (B) 1 and (C) 2 u/mL.

Product Details

Summary
Product Discontinued
View other related TRAF-2 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-77247
    • Availability
      Product Discontinued

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TRAF-2 Antibody Summary

Immunogen
Antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TRAF2. The immunogen is located within the last 50 amino acids of TRAF2.
Clonality
Polyclonal
Host
Rabbit
Gene
TRAF2
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
This antibody can be used for the detection of TRAF2 by Western blot at 0.5 - 1 mg/ml.

Reactivity Notes

Human, Mouse, Rat

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TRAF-2 Antibody

  • E3 ubiquitin-protein ligase TRAF2
  • EC 6.3.2.-
  • MGC:45012
  • TNF receptor-associated factor 2
  • TRAF2
  • TRAF-2
  • TRAP3
  • TRAP3TRAP
  • tumor necrosis factor type 2 receptor associated protein 3
  • Tumor necrosis factor type 2 receptor-associated protein 3

Background

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a TNF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappaB activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol TRAF2
Entrez
Uniprot