TRAF-2 Antibody


Western Blot: TRAF-2 Antibody [NBP1-42777] - Analysis of endogenous TRAF2 in whole HeLa cell lysates. Lane 2 shows endogenous TRAF2 detected with antibody at 47 kDa (arrowhead). Lane 4 shows no reactivity when blot is more

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TRAF-2 Antibody Summary

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region human TRAF-2.
The product was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody is predicted to react with TRAF2 from human and mouse sources based on a 100% identity with the immunizing sequence. Reactivity with TRAF2 from other sources has not been determined.
Immunogen affinity purified
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  • Western Blot 1 ug/ml
  • ELISA 1:60000-1:250000
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
TRAF-2 Lysate (NBP2-65475)

Reactivity Notes

Cross reactivity with TRAF-2 from other sources has not been tested.

Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.01% Sodium Azide
0.93 mg/ml
Immunogen affinity purified
Reconstitution Instructions
Reconstitute with 50 ul of distilled water to a final concentration of 1.0 mg/ml.

Alternate Names for TRAF-2 Antibody

  • E3 ubiquitin-protein ligase TRAF2
  • EC 6.3.2.-
  • MGC:45012
  • TNF receptor-associated factor 2
  • TRAF2
  • TRAF-2
  • TRAP3
  • tumor necrosis factor type 2 receptor associated protein 3
  • Tumor necrosis factor type 2 receptor-associated protein 3


TRAF2, or Tumor Necrosis factor (TNF) Receptor-Associated Factor 2, is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Association to the receptor is also mediated by the interaction with TRADD. TRAF2 mediates activation of NF-kappa-B and MAPK8/JNK and is involved in apoptosis. TRAF2 forms a heterodimeric complex with TRAF1, which then recruits the inhibitor-of-apoptosis proteins (IAPs), apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 for the inhibition of caspase activation. In this way it functions as a mediator of the anti-apoptotic signals from TNF receptors. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. TRAF2 may be involved in IL-15 signaling. Multiple alternatively spliced transcript variants exist, but the biological validity of only one transcript has been determined.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gene Symbol TRAF2