TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody

Images

 
Immunohistochemistry-Paraffin: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody [NB110-39047] - Analysis of anti-THRA antibody with human surface epithelium at concentration 10 ug/ml.

Product Details

Summary
Reactivity Hu, Mk, Pm, EqSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody Summary

Immunogen
Synthetic 16 amino acid peptide from ligand-binding domain of human THRA.
Epitope
ligand-binding domain of human
Specificity
Human THRA. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Equine (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
THRA
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 10 ug/ml

Reactivity Notes

Gorilla, Gibbon. Predicted cross-reactivity based on sequence identity: Hamster (88%), Rat (81%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody

  • AR7
  • c-ERBA-1
  • c-erbA-alpha
  • EAR7
  • EAR-7
  • EAR-7.1/EAR-7.2
  • ERBA
  • ERBA1thyroid hormone receptor, alpha (avian erythroblastic leukemia viral (v-erb-a)oncogene homolog)
  • ERBA-related 7
  • MGC000261
  • MGC43240
  • NR1A 1
  • NR1A1
  • NR1A1THRA3
  • Nuclear receptor subfamily 1 group A member 1
  • THRA
  • THRA1ERB-T-1
  • THRA2
  • thyroid hormone receptor alpha
  • thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a)oncogene homolog, avian)
  • TR alpha
  • triiodothyronine receptor
  • v-ErbA1
  • V-erbA-related protein 7

Background

Thyroid hormone receptor alpha (TR alpha), a NR1 Thyroid Hormone-Like Receptor, mediates the diverse actions of thyroid hormone in development, differentiation, and metabolism. Four protein isoforms are encoded by the same TR alpha genomic locus: TR alpha1 (410 aa) (Nakai et al. 1988), TR alpha2 (490 aa) (Nakai et al. 1988), TR deltaalpha1 (154 aa), and TR deltaalpha2 (237 aa); however, only TR alpha1 is able to bind the ligand (Lazar et al. 1988). TR alpha1 and TR alpha2 are products of alternative splicing of the primary TR alpha mRNA, whereas TR deltaalpha1 and TR deltaalpha2 arise from transcription of an internal promoter in intron 7 of the TR alpha gene. A truncated form of TR alpha, called p43 for 43-kDa, has been shown to regulate mitochondrial transcription Casas et al. 2003. Mice lacking all forms of TR alpha have been shown to be viable, but show reduced linear growth, delayed bone maturation, increased hypothermia, reduced thickness of the intestinal mucosa, lowered heart rates, and lowered serum T4. TR alpha has been linked to chronic fatigue Englebienne et al. 2003.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

1670-SE
Species: Ec
NBP2-56762
Species: Hu
Applications: WB, ICC/IF
NBP1-71770
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
NBP1-86919
Species: Hu
Applications: WB, IHC, IHC-P
NBP1-07100
Species: Hu, Mu
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P
NB200-585
Species: Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, CyTOF-ready, Flow-IC
NBP2-20619
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
NB200-322
Species: Hu, Mu, Rt
Applications: WB, IHC-Fr
NB100-598
Species: Hu
Applications: WB, Flow, ICC/IF, IP, CyTOF-ready
NB300-109
Species: Hu, Mu, Rt, Dr, I, Ma
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P, IHC-FrFl
AF231
Species: Hu
Applications: WB, Flow, IHC, IP, CyTOF-ready, ELISA(Cap), ELISA(Det), ICC, ELISA(Sta)
NB200-103
Species: Hu, Mu, Rt, Ye, Xp(-)
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, CyTOF-ready, Flow-IC
AF1067
Species: Hu, Mu, Rt
Applications: WB, IHC, Neut
H00009572-M02
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
NB300-537
Species: Hu, Mu, Rt, Bv, Rb
Applications: WB, ChIP, Flow, GS, ICC/IF, IHC, IHC-P, IP

Publications for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (NB110-39047) (0)

There are no publications for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (NB110-39047).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (NB110-39047) (0)

There are no reviews for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (NB110-39047). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (NB110-39047) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional TR alpha/NR1A1/Thyroid Hormone Receptor alpha Products

Bioinformatics Tool for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (NB110-39047)

Discover related pathways, diseases and genes to TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (NB110-39047). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (NB110-39047)

Discover more about diseases related to TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (NB110-39047).
 

Pathways for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (NB110-39047)

View related products by pathway.

PTMs for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (NB110-39047)

Learn more about PTMs related to TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (NB110-39047).
 

Research Areas for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (NB110-39047)

Find related products by research area.

Blogs on TR alpha/NR1A1/Thyroid Hormone Receptor alpha

There are no specific blogs for TR alpha/NR1A1/Thyroid Hormone Receptor alpha, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody and receive a gift card or discount.

Bioinformatics

Gene Symbol THRA
Entrez