TPMT Antibody (4B1)

Images

 
Western Blot: TPMT Antibody (4B1) [NBP2-02447] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TPMT (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ...read more
Immunohistochemistry-Paraffin: TPMT Antibody (4B1) [NBP2-02447] Staining of paraffin-embedded colon tissue using anti-TPMT mouse monoclonal antibody.
Immunohistochemistry-Paraffin: TPMT Antibody (4B1) [NBP2-02447] - Staining of paraffin-embedded Adenocarcinoma of colon tissue using anti-TPMT mouse monoclonal antibody.
Immunohistochemistry-Paraffin: TPMT Antibody (4B1) [NBP2-02447] - Staining of paraffin-embedded Carcinoma of liver tissue using anti-TPMT mouse monoclonal antibody.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP2-02447
    • Availability
      Product Discontinued

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TPMT Antibody (4B1) Summary

Immunogen
Full length human recombinant protein of human TPMT (NP_000358) produced in HEK293T cell.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TPMT
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.1% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for TPMT Antibody (4B1)

  • EC 2.1.1.67
  • S-adenosyl-L-methionine:thiopurine S-methyltransferase
  • Thiopurine methyltransferase
  • thiopurine S-methyltransferase

Background

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional TPMT Products

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Diseases for TPMT Antibody (NBP2-02447)

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Bioinformatics

Gene Symbol TPMT
Entrez