Toxoplasma Gondii Antibody [Biotin]

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Product Details

Summary
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    • Catalog Number
      NB100-65506
    • Availability
      Product Discontinued

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Toxoplasma Gondii Antibody [Biotin] Summary

Immunogen
Tachyzoites of RH strain of Toxoplasma gondii.
Specificity
NB100-64504 recognizes the RH strain of the coccidian parasite Toxoplasma gondii, a causitive agent of toxoplasmosis in many species of warm blooded animals. Felids are the only definitive host for T. gondii.. Infection is usually sub-clinical with symptoms depending on the level of tachyzoite release, the ability of the host to limit tachyzoite spread and the organs damaged by the tachyzoites. Immunocompetent adult animals generally limit tachyzoite spread and infection remains subclinical. However in young or immunocompromised animals infection can develop to an acute gereralised toxoplasmosis. T. gondii is an important zoonotic agent with up to 60% of some human populations demonstrating Serum IgG titers to the organism. These are likely to be persistently infected. The organism is of particular concern in immunocomprimised individuals such as those with HIV infection, who become increasingly susceptible to the organism as the immune system wanes. Infection is also of considerable concern in pregnant women as it can migrate across the placenta and cause birth defects in human foetuses.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:1000
Readout System

Reactivity Notes

Bacteria

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
IgG purified

Background

Toxoplasma is a crescent shaped sporozoan that lives as an intracellular parasite in various tissues of many vertebrates and completes its life cycle in a single host. Its life cycle includes two phases called the intestinal (or enteroepithelial) and extraintestinal phases. The intestinal phase produces oocysts and occurs only in cats, wild as well as domesticated. The extraintestinal phase occurs in all infected animals including cats, and produces tachyzoites (actively proliferating trophozoites) and eventually, bradyzoites (slowly growing trophozoites) or zoitocysts. Infection due to Toxoplasma gondii occurs in pregnant women where a variable degree of immunosuppression may exist or in patients receiving immunosuppressive drug therapy. Toxoplasma infects tissue of the GI tract where an active infection is accompanied by fever and enlargement of the spleen. Symptoms of toxoplasmosis are generally mild but severe infection of lymph nodes may occur. Congenital toxoplasmosis, in which the maternal infection is transmitted during pregnancy, can produce blindness or mental retardation in the newborn.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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