TOR/mTOR Antibody

Product Discontinued

TOR/mTOR Antibody Summary

• Immunogen: Synthetic peptide derived from the sequence of human mTOR
• Specificity: mTOR
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MTOR
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Reactivity Notes

Human, Mouse.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: No buffer
• Preservative: Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for TOR/mTOR Antibody

• EC 2.7.11.1
• FK506 binding protein 12-rapamycin associated protein 1
• FK506 binding protein 12-rapamycin associated protein 2
• FK506-binding protein 12-rapamycin complex-associated protein 1
• FKBP12-rapamycin complex-associated protein
• FLJ44809
• FRAP
• FRAP1
• FRAP1FKBP12-rapamycin complex-associated protein 1
• FRAP2
• Mammalian target of rapamycin
• mechanistic target of rapamycin (serine/threonine kinase)
• Mechanistic target of rapamycin
• MTOR
• RAFT1
• rapamycin and FKBP12 target 1
• rapamycin associated protein FRAP2
• Rapamycin target protein 1
• RAPT1FKBP-rapamycin associated protein
• serine/threonine-protein kinase mTOR
• TOR

Background

Mammalian target of rapamycin (mTOR) is an atypical serine-threonine protein kinase and member of the phosphatidylinositol 3-kinase (PI3K) signaling pathway. TORC1 (mTOR, GbetaL/mLST8 and Raptor) and TORC2 (mTOR, GbetaL/mLST8, SIN1, and Rictor) complexes control protein synthesis through the direct or indirect phosphorylation of downstream targets such as S6 Kinase and 4EBP1, key regulators of mRNA recruitment to ribosomes. Through its involvement in several key signaling pathways and its critical role in transcription and translation, mTOR mediates cell proliferation, differentiation, and survival. Recent studies identified the TORC2 complex as the missing kinase activator of Akt/PKB, deregulation of which has been implicated in the pathogenesis of cancer and diabetes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MTOR
• Entrez:
  • 2475(Human)
  • 56717(Mouse)