TLR3 Antibody [FITC]

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Product Details

Summary
Product Discontinued
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    • Catalog Number
      NB110-93591F
    • Availability
      Product Discontinued

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TLR3 Antibody [FITC] Summary

Immunogen
Synthetic peptide made to a C-terminal portion of the human TLR3 protein (within residues 800-904). [Swiss-Prot# O15455]
Localization
Cell membrane; Single-pass type I membrane protein
Predicted Species
Mouse (92%), Rat (92%), Bovine (92%), Equine (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TLR3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Application Notes
This TLR3 antibody is useful for Western blot, where a band is seen at ~105 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
105 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, primate, porcine and feline. 92% sequence identity with mouse, rat, equine and bovine

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TLR3 Antibody [FITC]

  • CD283 antigen
  • CD283
  • TLR3
  • toll-like receptor 3

Background

TLR3 (toll-like receptor 3) receptors are a key component of immune system, and represents an intracellular recognition system that specifically respond to RNA viral infections with its unique nucleotide-sensing capability. TLR3 is activated by double-stranded RNAs, and it triggers the production of type 1 IFN as well as inflammatory cytokines/chemokines. TLR3 acts via MYD88/TRAF6 resulting in NFkB activation and cytokine secretion followed by inflammatory response. TLR3 is expressed by epithelial cells, a broad range of antigen-processing cells, tissue dendritic cells, monocytes, mast cells, NK cells etc. TLR3 signaling results in a local cytokine burst which is microenvironment- and cell-specific in nature and leads to local inflammatory response adaptively selected to provide a greatest chance of infection control for affected tissues. TLR3 activation also leads to local production of acute response molecules such as type I IFN, TNF-alpha, IL-12, MCP-1 etc. Defects in TLR3 have been linked to herpes simplex encephalitis type 2 (HSE2) and TLR3 agonists are emerging as promising adjuvants in dendritic cells - based immunotherapy for the treatment of viral and neoplastic diseases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics Tool for TLR3 Antibody (NB110-93591F)

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Research Areas for TLR3 Antibody (NB110-93591F)

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Blogs on TLR3.

The role of STING/TMEM173 in gamma and encephalitis Herpes Simplex Virus (HSV)
Stimulator of interferon genes (STING), also known as TMEM173, promotes the production of the interferon’s IFN-alpha and IFN-beta.  STING possesses three functional domains: a cytoplasmic C-terminal tail, a central globular domain, and four N-...  Read full blog post.

TRIF/TICAM1 and mitochondrial dynamics in the innate immune response
TRIF, also known as toll like receptor adaptor molecule 1 or TICAM1, is known for its role in invading foreign pathogens as part of our innate immune response. TRIF/TICAM1 is a TIR-domain adaptor protein (toll/interleukin-1 receptor) that interacts...  Read full blog post.

The role of TLR4 in breast cancer
Toll like receptors (TLRs) are highly conserved proteins that are first known for their role in pathogen recognition and immune response activation.  In order to elicit the necessary immune response in reaction to a foreign pathogen, TLRs trigger cy...  Read full blog post.

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Bioinformatics

Gene Symbol TLR3
Entrez