TLR3 Antibody (T3.7C3)

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Product Details

Summary
Product Discontinued
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    • Catalog Number
      NBP1-43143
    • Availability
      Product Discontinued

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TLR3 Antibody (T3.7C3) Summary

Immunogen
The immunogen for this antibody was Tolllike receptor 3.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
TLR3
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
Application Notes
The T3.7C3 antibody has been tested by immunoblotting of mTLR3 transfected cell lysate and can be used at 1-3ug/ml.

Reactivity Notes

This antibody is reactive to Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Aqueous, may contain carrier protein/stabilizer.
Preservative
0.09% Sodium Azide
Purity
Protein A or G purified

Alternate Names for TLR3 Antibody (T3.7C3)

  • CD283 antigen
  • CD283
  • TLR3
  • toll-like receptor 3

Background

The T3.7C3 antibody reacts with mouse TLR3 and was generated using the sequence of extracellular domain of mouse TLR3. To date, at least twelve members of the Toll family have been identified. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. In the innate immunity system, TLRs recognize molecular patterns associated with microbial pathogens and induce antimicrobial immune responses. TLR3 recognizes double-stranded (ds)RNA and induces the activation of NF-kappaB, through MyD88-dependent and -independent pathways and the production of type I interferons (IFNs). Immunoblotting with this antibody gives a MW of ~120 kDa in mTLR3 transfected cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Blogs on TLR3.

The role of STING/TMEM173 in gamma and encephalitis Herpes Simplex Virus (HSV)
Stimulator of interferon genes (STING), also known as TMEM173, promotes the production of the interferon’s IFN-alpha and IFN-beta.  STING possesses three functional domains: a cytoplasmic C-terminal tail, a central globular domain, and four N-...  Read full blog post.

TRIF/TICAM1 and mitochondrial dynamics in the innate immune response
TRIF, also known as toll like receptor adaptor molecule 1 or TICAM1, is known for its role in invading foreign pathogens as part of our innate immune response. TRIF/TICAM1 is a TIR-domain adaptor protein (toll/interleukin-1 receptor) that interacts...  Read full blog post.

The role of TLR4 in breast cancer
Toll like receptors (TLRs) are highly conserved proteins that are first known for their role in pathogen recognition and immune response activation.  In order to elicit the necessary immune response in reaction to a foreign pathogen, TLRs trigger cy...  Read full blog post.

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Bioinformatics

Gene Symbol TLR3
Entrez