TIMP-2 Antibody

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-41504
    • Availability
      Product Discontinued

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TIMP-2 Antibody Summary

Immunogen
A peptide mapping at the C-terminal end of TIMP-2 of human origin, identical to the related rat and mouse sequence
Clonality
Polyclonal
Host
Rabbit
Gene
TIMP2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-2 ul/ml

Reactivity Notes

Human, Mouse, Rat

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.2 mg DiSodium Phosphate, 0.9 mg NaCl and 5 mg BSA
Preservative
0.05mg Thimerosal
Purity
Immunogen affinity purified

Alternate Names for TIMP-2 Antibody

  • CSC-21Ktissue inhibitor of metalloproteinase 2
  • metalloproteinase inhibitor 2
  • TIMP metallopeptidase inhibitor 2
  • TIMP2
  • TIMP-2
  • Tissue inhibitor of metalloproteinases 2

Background

Matrix metalloproteinases (MMPs) are a family of enzymes that are responsible for the degradation of extracellular matrix components such as collagen, laminin and proteoglycans. These enzymes are involved in normal physiological processes such as embryogenesis and tissue remodeling and may play an important role in arthritis, periodontitis, and metastasis. The activation and activity of MMPs are regulated by a family of endogenous inhibitors, tissue inhibitors of metalloproteinase (TIMP). TIMP2 (also called CSC-21K) is a 21 kDa glycoprotein that is expressed by a variety of cell types. It forms a non covalent, stoichiometric complex with both latent and active MMPs. TIMP2 shows a preference for MMP2. TIMPs are capable of altering the metastatic potential of cancer cells and have been shown to inhibit invasion and metastasis in animal models. TIMP2 is constitutively produced in low (pg/ml) levels by most cell types in tissue culture. The low protein levels produced often require concentration of cell culture media to visualize the bands by Western Blotting.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for TIMP-2 Antibody (NBP1-41504). (Showing 1 - 1 of 1 FAQ).

  1. Can you please send me the amino acid sequence of the peptide used for immunization for NBP1-41504?
    • The sequence is RGAAPPKQEFLDIEDP.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for TIMP-2 Antibody (NBP1-41504)

Discover related pathways, diseases and genes to TIMP-2 Antibody (NBP1-41504). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for TIMP-2 Antibody (NBP1-41504)

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PTMs for TIMP-2 Antibody (NBP1-41504)

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Bioinformatics

Gene Symbol TIMP2
Entrez