Tie-1 Antibody

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Immunohistochemistry-Paraffin: TIE1 Antibody [NBP1-36589] Human Tonsil

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-36589
    • Availability
      Product Discontinued

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Tie-1 Antibody Summary

Immunogen
Synthetic peptide corresponding to C-terminal of human Tie-1.
Specificity
This product is specific for Tie-1
Clonality
Polyclonal
Host
Rabbit
Gene
TIE1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:100

Reactivity Notes

This product is specific for Human.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
10mM PBS (pH 7.4)
Preservative
0.1% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Tie-1 Antibody

  • EC 2.7.10
  • EC 2.7.10.1
  • JTK14soluble TIE1 variant 3
  • receptor tyrosine kinase
  • soluble TIE1 variant 1
  • soluble TIE1 variant 2
  • soluble TIE1 variant 5
  • Tie1
  • Tie-1
  • TIEsoluble TIE1 variant 4
  • tyrosine kinase with immunoglobulin and epidermal growth factor homologydomains 1
  • tyrosine kinase with immunoglobulin-like and EGF-like domains 1
  • tyrosine-protein kinase receptor Tie-1

Background

TIE1/TIE (tyrosine kinase with Ig and EGF homology domains 1) and TIE2/Tek define a new class of the receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin like domains flanking three epidermal growth factor (EFG) like domains followed by three fibronectin type III like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. Human TIE1 cDNA encodes a 1138 amino acid residue precursor protein with a putative signal peptide, an extracellular domain, and a cytoplasmic domain. Human TIE1/Fc, a disulfide linked homodimeric protein, has a calculated molecular mass of approximately 107 kDa. Due to glycosylation, the protein migrates to approximately 160 kDa in SDS PAGE under reducing conditions. TIE1 and TIE2, expressed primarily on endothelial and hematopoietic progenitor cells, play important roles in angiogenesis, vasculogenesis, and hematopoiesis. In developing vascular endothelial cells, TIE1 and TIE2 are specifically expressed. Two ligands that bind TIE have been identified, angiopoietin 1 and angiopoietin 2. Based on gene targeting studies, the in vivo functions of TIE1 are related to endothelial cell differentiation. The receptor tyrosine kinase TIE also plays a role in the survival and integrity of the endothelium.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Additional Tie-1 Products

Bioinformatics Tool for Tie-1 Antibody (NBP1-36589)

Discover related pathways, diseases and genes to Tie-1 Antibody (NBP1-36589). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Tie-1 Antibody (NBP1-36589)

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Bioinformatics

Gene Symbol TIE1
Entrez