Thyroglobulin Antibody (RBU/01)

Product Discontinued

Thyroglobulin Antibody (RBU/01) Summary

• Immunogen: BALB/C mice were injected with purified human thyroglobulin.
• Localization: Cytoplasmic
• Specificity: This antibody is specific to the 330 kD protein. Thyroglobulin is synthesized by follicular epithelial cells of the thyroid. Thyroglobulin has been useful in the positive identification of thyroid carcinomas of the papillary and follicular types. It stains thyroglubulin in adenoma from thyroid (microfollicles). This antibody cross-reacts with human, bovine, porcine, goat, and guinea pig thyroglobulin.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TG
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
• Application Notes: Immunohistochemistry-Paraffin Intended Use: This product is intended for qualitative immunohistochemistry with normal and neoplastic formalin-fixed, paraffin-embedded tissue sections, to be viewed by light microscopy. Clinical interpretation of staining results should be accompanied by histological studies with proper controls. Patients? clinical histories and other relevant diagnostic tests should be utilized by a qualified person(s) when evaluating and interpreting results. Staining Protocol: We suggest an incubation period of 30 minutes at room temperature. Optimal incubation conditions should be determined by the user based upon the fixation conditions and staining system employed. Suitable for formalin fixed paraffin embedded tissues. No special pretreatment is required.

Reactivity Notes

Human, Bovine, Porcine, Goat, and Guinea pig

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Ascites
• Preservative: Sodium Azide
• Purity: Unpurified

Notes

Intended Use: This product is intended for qualitative immunohistochemistry with normal and neoplastic formalin-fixed, paraffin-embedded tissue sections, to be viewed by light microscopy. Clinical interpretation of staining results should be accompanied by histological studies with proper controls. Patients? clinical histories and other relevant diagnostic tests should be utilized by a qualified person(s) when evaluating and interpreting results. Staining Protocol: We suggest an incubation period of 30 minutes at room temperature. Optimal incubation conditions should be determined by the user based upon the fixation conditions and staining system employed. Suitable for formalin fixed paraffin embedded tissues. No special pretreatment is required.

Alternate Names for Thyroglobulin Antibody (RBU/01)

• AITD3
• AITD3TGN
• cog
• TDH3
• Tg
• TGN
• Thyroglobulin

Background

Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti thyroglobulin autoantibodies were the first factor to be discovered. Anti hTG is found in all thyroid autoimmune diseases (Hashimoto's thyroiditis, Graves' diseases), with the highest level observed in Hashimoto's thyroiditis. Anti hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TG