Thymopoietin/LAP2 Antibody (RL29)



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Thymopoietin/LAP2 Antibody (RL29) Summary

Pore complex-lamina fraction isolated from rat liver nuclear envelopes.
Nuclear and Secreted
Inner-nuclear Membrane Marker
Detects Lamin Associated Polypeptide (LAP) 2 from various rat tissues but does not cross-react with LAP 1A, 1B & 1C.This recognizes a single 53 kDa protein representing LAP 2 in rat liver nuclear envelope fractions.
Armenian Hamster
Protein A or G purified
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  • Western Blot 1:1
  • Immunocytochemistry/Immunofluorescence 1:100000
  • Immunoprecipitation 1:10-1:500
Application Notes
Immunofluorescence: use at 1:100 Immunoprecipitation: Assay dependentWestern Blot: use at 1:1000Optimal dilutions should be determined by the individual.
Positive Control
Thymopoietin/LAP2 Lysate (NBP2-66028)

Reactivity Notes

Cross-reacts with Rat.Not yet tested in other species.

Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
0.05% Sodium Azide
Protein A or G purified

Alternate Names for Thymopoietin/LAP2 Antibody (RL29)

  • CMD1T
  • lamina-associated polypeptide 2
  • LAP2PRO0868
  • LEM domain containing 4
  • LEMD4
  • MGC61508
  • Thymopoietin isoform alpha
  • Thymopoietin
  • Thymopoietin, isoforms beta/gamma
  • Thymopoietin-related peptide isoform alpha
  • Thymopoietin-related peptide isoforms beta/gamma
  • TMPO
  • TP alpha
  • TP beta/gamma
  • TP
  • TPRP isoform alpha
  • TPRP isoforms beta/gamma


In eukaryotic cells, the nuclear envelope consists of inner and outer membranes which define the border between the nucleus and cytoplasm. The inner and outer nuclear membranes are joined by large, supramolecular assemblies called nuclear pore complexes through which various molecules pass into and out of the nucleus. The inner membrane is lined by a filamentous meshwork called the nuclear lamina made up of proteins called lamins. The attachment of the lamins to the inner nuclear membrane appears to occur through their association with 4 related integral membrane proteins called Lamin Associated Polypeptides (LAPs). LAP 1A, 1B & 1C share a high degree of sequence homology while LAP 2 is distinct from the others. LAP 1A & B bind lamins A, C and B1, while LAP 2 binds lamin B1 only. In addition to lamin binding, LAP 2 has been shown to bind to chromosomes. Phosphorylation of LAP 2 during mitosis inhibits binding to both lamins and chromosomes suggesting that LAP 2 plays an important role in nuclear envelope re-assembly.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies


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Gene Symbol TMPO