Thymidine Kinase 1 Antibody

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Western Blot: Thymidine Kinase 1 Antibody [NB100-60643] - Detection of Human TK1 by Western Blot ofImmunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity ...read more

Product Details

Summary
Product Discontinued
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    • Catalog Number
      NB100-60643
    • Availability
      Product Discontinued

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Thymidine Kinase 1 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 165 and 205 of human thymidine kinase 1 using the numbering given in entry NP_003249.1 (GeneID 7083).
Clonality
Polyclonal
Host
Rabbit
Gene
TK1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunoprecipitation 1:10-1:500

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Thymidine Kinase 1 Antibody

  • EC 2.7.1.21
  • thymidine kinase 1 soluble isoform
  • Thymidine Kinase 1
  • thymidine kinase 1, soluble
  • thymidine kinase, cytosolic
  • thymidine kinase-1
  • TK1
  • TK2

Background

Thymidine kinase (TK) belongs to a group of enzymes such as dihydrofolate reductase, thymidylate synthase, and DNA polymerase that are involved in DNA synthesis and precursor production. Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells due to multiple regulatory mechanisms that ensure expression of these enzymes exclusively in replicating cells. TK is responsible for catalyzing the phosphorylation of thymidine, which functions as a part of the pyrimidine salvage pathway involved in DNA synthesis. The activities of enzymes such as TK are essential for the activation of several chemotherapeutically important nucleoside analogues that are administered as prodrugs.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol TK1
Entrez
Uniprot