Th-POK Antibody



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Product Discontinued
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Th-POK Antibody Summary

This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal sequence of mouse cKrox protein.
This antibody is directed against mouse cKrox. A BLAST analysis was used to suggest cross-reactivity with c-Krox from mouse, human and rat based on a 100% identity with the immunizing sequence.
Delipidation and Defibrination
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Packaging, Storage & Formulations

Store at 4C. Do not freeze.
20mM Sodium Phosphate (pH 7.2) and 0.15M NaCl
0.01% Sodium Azide
Delipidation and Defibrination


Application Notes
Expect a band approximately 80 kDa in size corresponding - cKrox by western blotting in the appropriate cell lysate or extract. Lysates from mouse thymocytes are recommended for use as positive controls.

Reactivity Notes

Reactive in mouse, human, rat


cKrox (also known as Zfp67 or ThPOK) functions as a transcription regulator that acts as a key modulator of lineage commitment for immature T-cell precursors. cKrox is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. cKrox is a known transcriptional repressor of the collagen COL1A1 and COL1A2 genes and may also function as a repressor of fibronectin and possibly other extracellular matrix genes. cKrox is located within the nucleus and is expressed in multiple tissues and organs including skin, thymus and peripheral T-cells.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product PDFs


Gene Symbol ZBTB7B

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