TET1 Antibody



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TET1 Antibody Summary

Within the range of amino acids 1140-1178 of human TET1 were used as the immunogen for this antibody.
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
100 ul; crude rabbit sera with 50% glycerol.
0.025% Sodium Azide
This product is unpurified. The exact concentration of antibody is not quantifiable.

Reactivity Notes

The amino acid sequence used as immunogen is 100% homologous in human, white-cheeked gibbon, chimpanzee, orangutan and pig, 95% in new world monkey, rhesus monkey and rabbit 84% in panda, cow, dog and european pole-cat, 79% in naked mole rat and african bush elephant and 74% homolgous in guinea pig.


Tet1 is a member of the Ten-eleven family of proteins that convert 5-methyl cytosine to 5- hydroxymethylcytosine (1-3). Tet1 protein is an enzyme which has a molecular weight of 235kDa and has been found to be expressed in murine embryonic stem cells. It appears that Tet1 is a required protein for ES maintenance as an important epigenetic DNA modification protein. Through preferential binding to CpG rich sequences in transcriptionally active as well as Polycomb-repressed genes, Tet1 functions as a DNA methylation regulator and modulator of pluripotency markers (4). Tet1 antibody should be useful as an expression marker for differentiation and self-renewal status of stem cells.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product PDFs


Gene Symbol TET1

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