TEM7/PLXDC1 Antibody

Images

 
Western Blot: TEM7/PLXDC1 Antibody [NBP1-40282] - Analysis of anti-TEM7 antibody with rat liver tissue lysate at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemistry-Paraffin: TEM7/PLXDC1 Antibody [NBP1-40282] - Analysis of anti-TEM7 antibody with human kidney at concentration 5 ug/ml.

Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications WB, ELISA, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

TEM7/PLXDC1 Antibody Summary

Immunogen
Synthetic peptide from human PLXDC1 / TEM7.
Specificity
a 16 amino acid peptide from near the center of human TEM7
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PLXDC1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5-1 ug/ml
  • ELISA 1:100 - 1:2000
  • Immunohistochemistry-Paraffin 5 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TEM7/PLXDC1 Antibody

  • FLJ45632
  • plexin domain containing 1,2410003I07Rik
  • plexin domain-containing protein 1
  • PLXDC1
  • TEM3
  • TEM3FLJ36270
  • TEM7
  • TEM7DKFZp686F0937
  • Tumor endothelial marker 3
  • Tumor endothelial marker 7

Background

Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Bioinformatics

Gene Symbol PLXDC1
Entrez
Uniprot