Recombinant Human TCL1A Protein

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SDS-Page: TCL1 Protein [NBP1-30239] - TCL1A,13.4 kDa (114aa), confirmed by MALDI-TOF with a purity of 90% by SDS - PAGE

Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
1 mg/ml

Order Details

Recombinant Human TCL1A Protein Summary

Description
An un-tagged recombinant protein corresponding to the amino acids 1-114 of Human TCL1A

Source: E.coli

Amino Acid Sequence: MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
TCL1A
Purity
>90%, by SDS-PAGE

Applications/Dilutions

Theoretical MW
13.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
50mM Tris-HCl buffer (pH7.5) containing 10% glycerol
Preservative
No Preservative
Concentration
1 mg/ml
Purity
>90%, by SDS-PAGE

Alternate Names for Recombinant Human TCL1A Protein

  • Oncogene TCL1
  • Oncogene TCL-1
  • Protein p14 TCL1
  • T-cell leukemia/lymphoma 1A
  • T-cell lymphoma-1
  • T-cell lymphoma-1A
  • TCL1A
  • TCL1-PEN
  • TCL1T-cell leukemia/lymphoma protein 1A

Background

TCL1A, also known as T-cell leukemia/lymphoma 1A, is a protein with a suggested role in intracellular regulation of T cell signaling. TCL1A binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity TCL1A may enhance the serine/threonine phosphorylation of major Akt signaling substrates, such as Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors, and GSK3b. These substrates regulate cellular differentiation, growth, survival, and metabolism. Recombinant TCL1A protein was expressed in E.coli and purified by using conventional chromatography techniques

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol TCL1A
Entrez