Tau [p Ser262] Antibody

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Western Blot: Tau Antibody [NB100-92651]

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-92651
    • Availability
      Product Discontinued

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Tau [p Ser262] Antibody Summary

Immunogen
Synthetic phosphopeptide derived from human Tau around the phosphorylation site of Serine 262.
Modification
p Ser262
Marker
pan-Neuronal Marker
Clonality
Polyclonal
Host
Rabbit
Gene
MAPT
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
Application Notes
Western blot (WB) analysis of p-Tau (S262) pAb in extracts from A549 and sp20 cells
Theoretical MW
80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Positive Control
Tau Lysate (NBL1-12894)

Reactivity Notes

Cross reacts with Human, Mouse and Rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Tau [p Ser262] Antibody

  • DDPAC
  • FLJ31424
  • FTDP-17
  • G protein beta1/gamma2 subunit-interacting factor 1
  • MAPT
  • MGC138549
  • microtubule-associated protein tau
  • MSTD
  • MSTDMAPTL
  • MTBT1
  • MTBT1Neurofibrillary tangle protein
  • MTBT2
  • Neurofibrillary tangle protein
  • PHF-tau
  • PPND
  • Tau
  • TAUPaired helical filament-tau

Background

Glycogen synthase kinase-3, or GSK-3, is a Serine/Threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion, and is implicated in Alzheimer's disease. Tau, a microtubule binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments(PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer's disease. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. The biological activity of the phosphoprotein Tau is regulated by its degree of phosphorylation. PKA, a nonprolinedirected kinase, phosphorylates Tau on Ser 214 and GSK-3 phosphorylatesTau on Ser 396.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Tau Antibody (NB100-92651). (Showing 1 - 1 of 1 FAQ).

  1. Could I learn the molecular weight Tau [Ser262] Antibody detects?
    • You should see an 85kDa band on your blots. There may also be other bands present which may correspond to different isoforms of the protein with the most prominent one at 49kDa. The presence and number of extra bands will depend on sample type (different tissues and cell lines).

Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Tau Antibody (NB100-92651)

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Research Areas for Tau Antibody (NB100-92651)

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Blogs on Tau.

The C99 fragment of amyloid precursor protein (APP)
Alzheimer’s Disease (AD) is a neurodegenerative disorder that is characterized by an abundance of the beta-amyloid peptide in the brain.  When AD was first discovered, it was determined that beta-amyloid was produced as a result of the prote...  Read full blog post.

Tau - A microtubule associated protein as a biomarker for Alzheimer's disease
The tau protein is a microtubule associated protein found mostly in neuronal cells where it regulates the stability of axonal microtubules as well as kinesin-dependent transport. Tau is relevant in the study of various neurological disorders as ab...  Read full blog post.

PINK1: All work and no fun
The protein PINK1 is a mitochondrial-located serine/threonine kinase (PTK) that maintains organelle function and integrity. It not only protects organelles from cellular stress, but it also uses the selective auto-phagocytosis process for cleaning and...  Read full blog post.

Using Amyloid beta peptides in Alzheimer's Disease Immunization
Amyloid beta (AB) peptide has a central role in the neurodegeneration of Alzheimer's disease (AD). Immunization of AD transgenic mice with AB-42 peptide reduces both the spatial memory impairments and AD-like neuropathologic changes.Therapeutic im...  Read full blog post.

New Study Links Tau Mutations to Microglial Immune Response
Tau proteins are abundant in the axons of neurons in the central nervous system (CNS), and play a key role in microtubule formation and stabilization. Antibody studies have identified six tau isoforms, all produced by alternative mRNA splicing of the...  Read full blog post.

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Bioinformatics

Gene Symbol MAPT
Entrez