t-Plasminogen Activator/tPA Overexpression Lysate (Denatured)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB

Order Details

t-Plasminogen Activator/tPA Overexpression Lysate (Denatured) Summary

Description
Pasmid: pCMV-PLAT full-length
Gene
PLAT

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, and 0.01% Bromophenol blue).

Lysate Details for t-Plasminogen Activator/tPA

Type
Overexpression
Protein State
Denatured

Notes

Quality control test: Transient overexpression cell lysate was tested with Anti-PLAT antibody by Western Blots.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for t-Plasminogen Activator/tPA Overexpression Lysate (Denatured)

  • Alteplase
  • DKFZp686I03148
  • EC 3.4.21
  • EC 3.4.21.68
  • plasminogen activator, tissue type
  • plasminogen activator, tissue
  • PLAT
  • Reteplase
  • tissue plasminogen activator (t-PA)
  • tissue-type plasminogen activator
  • TPA
  • T-PA
  • tPlasminogen Activator
  • t-Plasminogen Activator

Background

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq]. Transcript Variant: This variant (3) lacks exon 4 but the reading frame is maintained, as compared to variant 1. It encodes isoform 3 which is 46 aa shorter than isoform 1. The absence of these 46 aa makes it unlikely that isoform 3 forms a two chain disulfide linked protein like isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Lysates are guaranteed for 6 months from date of receipt.

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Publications for t-Plasminogen Activator/tPA Lysate (H00005327-T01) (0)

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Bioinformatics

Gene Symbol PLAT
Entrez