Synuclein-alpha Antibody (2B2D1)

Images

 
Western Blot: alpha-Synuclein Antibody (2B2D1) [NB110-60492] - Figure 1: Western blot analysis using anti-human monoclonal antibody against truncated recombinant protein.
Immunohistochemistry: alpha-Synuclein Antibody (2B2D1) [NB110-60492] - Figure 2: Immunohistochemical analysis of paraffin-embedded human glioma tissue, showing membrane localization, using alpha-Synuclein Antibody ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC, IHC-Fr, IHC-P
Clone
2B2D1
Clonality
Monoclonal
Host
Mouse

Order Details

Synuclein-alpha Antibody (2B2D1) Summary

Immunogen
Ni-NTA purified truncated recombinant alpha-Synuclein Antibody (2B2D1) expressed in E. Coli strain BL21 (DE3)
Specificity
alpha-Synuclein Antibody (2B2D1)
Clonality
Monoclonal
Host
Mouse
Gene
SNCA
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Conjugate
Unconjugated
Buffer
Ascites
Preservative
0.03% Sodium Azide
Purity
Unpurified

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500

Reactivity Notes

Human

Alternate Names for Synuclein-alpha Antibody (2B2D1)

  • Lewy body) 4
  • MGC110988
  • NACP
  • non A-beta component of AD amyloid
  • Non-A beta component of AD amyloid
  • Non-A4 component of amyloid precursor
  • non-A4 component of amyloid
  • PARK1
  • PARK4
  • PD1
  • SNCA
  • synuclein, alpha (non A4 component of amyloid precursor)
  • Synucleinalpha
  • Synuclein-alpha

Background

Alpha-synuclein (SNCA), with 140-amino acid protein (about 15kDa), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Synuclein-alpha Antibody (NB110-60492). (Showing 1 - 1 of 1 FAQ).

  1. I'm looking for an alpha-Synuclein antibody with an epitope located in the first half (N-terminus) of the protein - preferably a monoclonal antibody. Can you help me with that?
    • Please take a look at NB110-57475. It has been validated for human, rat and mouse and the applications ICC and WB and the epitope it detects is in the N terminal.

Secondary Antibodies

 

Isotype Controls

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Blogs on Synuclein-alpha.

alpha-Synuclein - a small protein with big implications in neurodegeneration
alpha-Synuclein is a 14 kDa protein encoded by the SNCA gene that is abundantly expressed in neurons. Within the neuron, alpha-Synuclein is densely localized on presynaptic terminals, indicating a potential role in synaptic transmission. Nitration...  Read full blog post.

Contact Information

Product PDFs

Bioinformatics

Gene Symbol SNCA
Entrez

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