SYK [p Tyr525] Antibody

Images

 
Western Blot: SYK [p Tyr525] Antibody [NBP1-51392] - NBP1-51392 in extracts from A549 cells.
Immunohistochemistry-Paraffin: SYK [p Tyr525] Antibody [NBP1-51392] - Analyzes of p-Syk (Y525) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51392
    • Availability
      Product Discontinued

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SYK [p Tyr525] Antibody Summary

Immunogen
Synthetic phosphopeptide derived from human Syk around the phosphorylation site of Tyrosine 525.
Modification
p Tyr525
Specificity
p-Syk (Y525) pAb detects endogenous levels of Syk protein only when phosphorylated at Y525
Clonality
Polyclonal
Host
Rabbit
Gene
SYK
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500- 1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Theoretical MW
72 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using
NBP1-51392 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SYK [p Tyr525] Antibody

  • DKFZp313N1010
  • EC 2.7.10
  • EC 2.7.10.2
  • FLJ25043
  • spleen tyrosine kinaseFLJ37489
  • SYK
  • tyrosine-protein kinase SYK

Background

Syk (72 kDa) is a non receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration.SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SYK Antibody (NBP1-51392)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC-P.


Filter By Application
IHC-P
(1)
All Applications
Filter By Species
Mouse
(1)
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Bioinformatics

Gene Symbol SYK
Entrez