SYK [p Tyr348] Antibody

Images

 
Western Blot: SYK [p Tyr348] Antibody [NB100-92645] - Western blot (WB) analysis of SYK [p Tyr348] antibody in extracts from COS7 treated with EGF 200ng/ml 30min or COLO treated with PMA 125ng/ml 30min or Jurkat.
Immunohistochemistry: SYK [p Tyr348] Antibody [NB100-92645] - Analyzes of SYK [p Tyr348] antibody in paraffin-embedded human breast carcinoma or lung carcinoma tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-92645
    • Availability
      Product Discontinued

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SYK [p Tyr348] Antibody Summary

Immunogen
Synthetic phosphopeptide derived from human Syk around the phosphorylation site of Tyrosine 348.
Modification
p Tyr348
Clonality
Polyclonal
Host
Rabbit
Gene
SYK
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500- 1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of p-SYK (Y348) pAb in extracts from COS7 cells.
Immunohistochemistry (IHC) analyzes of p-SYK (Y348) pAb in paraffin-embedded human breast carcinoma or lung carcinoma tissue.
Theoretical MW
72 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using
NB100-92645 in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SYK [p Tyr348] Antibody

  • DKFZp313N1010
  • EC 2.7.10
  • EC 2.7.10.2
  • FLJ25043
  • spleen tyrosine kinaseFLJ37489
  • SYK
  • tyrosine-protein kinase SYK

Background

The Src-related protein tyrosine kinases Lck p56 and Fyn p59 are critically involved in T cell antigen receptor (TCR)/CD3-triggered activation. T lymphocytes also express a second class of non-receptor protein tyrosine kinases, Syk p70 and ZAP p72. These kinases resemble the Src family protein tyrosine kinases in that they have a C-terminal catalytic domain, but differ in that they are characterized by two SH2 domains but no SH3 domains. Evidence for the involvement of the Syk/ZAP family proteins in T cell activation was suggested by the finding that Syk p72 kinase fused to the transmembrane and extracellular domains of CD7 and DC16, respectively, can induce complete T cell activation. In contrast, the ZAP p70 kinase was insufficient unless it was coaggregated with a Fyn p59-containing chimera, suggesting that regulation of ZAP p70 activity may require a functional interaction with Src family kinases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SYK Antibody (NB100-92645)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.


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WB
(1)
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Bioinformatics

Gene Symbol SYK
Entrez
Uniprot