Substance P Antibody (NC1/34)

Images

 
There are currently no images for Substance P Antibody (NB100-65219).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications ICC/IF, IHC, IHC-Fr, IHC-P, IHC-WhMt
Clone
NC1/34
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated

Order Details

Substance P Antibody (NC1/34) Summary

Immunogen
Substance P conjugated to Bovine Serum Albumin.
Specificity
NB100-65219 recognizes the COOH terminal end of substance P, a short polypeptide neurotransmitter that regulates the excitability of dorsal horn nociceptive neurons. It is known to have a role in several physiologic activities such as pain transmission, the vomiting reflex, salivary secretion and smooth muscle contraction. 5% reactivity is observed with eledoisin. It does not react with Leu or Met-enkephalin, somatostatin or beta-endorphin.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
TAC1
Purity
Tissue culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:100-1:200
  • Immunohistochemistry-Paraffin 1:100-1:200
  • Immunohistochemistry Whole-Mount
Application Notes
Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin and Immunofluorescence. This product does not require antigen retrieval prior to staining of formalin fixed, paraffin embedded sections. This antibody has been used for the localization of substance P in tissue sections by immunofluorescence and PAP staining in nervous systems of experimental animals and man. Please refer to the Cuello references listed below. It has also been successfully applied in archive post-mortem tissues of the human brain, see Mai and Pioro references. Use in Immunohistochemistry whole mount reported in scientific literature (PMID 24728885)
Reviewed Applications
Read 1 Review rated 4
using
NB100-65219 in the following applications:

Publications
Read Publication using
NB100-65219 in the following applications:

Reactivity Notes

May react with the following species: Bichir, Bovine, Bullfrog, Calanus sp. Cancer sp., Chicken, Chinchilla, Cockroach, Cowbird, Crayfish, Crustacea, Guinea Pig, Homarus sp., Lamprey, Mammals, Mudpuppy, Panilurus sp., Pig, Pigeon, Rabbit, Rat, Sheep, Spadefoot toad, Zebrafish. Amphibia is expected from sequence similiarity. Mouse reactivity reported in scientific literature (PMID: 24728885)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Tissue culture supernatant
Preservative
0.05% Thimerosal
Purity
Tissue culture supernatant

Alternate Names for Substance P Antibody (NC1/34)

  • neurokinin 1
  • neurokinin 2
  • neurokinin A
  • Neurokinin-1
  • neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
  • neuropeptide gamma
  • neuropeptide K
  • NK2
  • NKA
  • NKNAneurokinin alpha
  • NPK
  • PPT
  • protachykinin-1
  • substance K
  • Substance P
  • TAC1
  • TAC2neuromedin L
  • tachykinin 2
  • tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2
  • tachykinin, precursor 1

Background

Substance P (SP) is currently thought to be one of the most important neurotransmitters and neurotransmitters in the brain. It is an undecapeptide belonging to the tachykinin family, which consists of excitatory neuropeptides synthesized in neuronal and glial cells of the human central and peripheral nervous system. Substance P, Neurokinin A, Neuropeptide K, and Neuropeptide gamma are all generated by post-translation cleavage of the precursor Protachykinin-1. Substance P forms the major endogenous ligand for Neurokinin 1 Receptor. The pharmacology of Substance P has been associated with a number of neurological and psychiatric disorders, namely nociception, migraine, asthma, nausea, inflammatory bowel syndrome, urinary incontinence, anxiety and depression. It has also been linked to obesity. This antibody reacts with substance P, a bioactive peptide secreted from neurons both in the gut and central nervous system. Can be used for the localisation of Substance P in cells and tissues.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

MAB4077
Species: Hu
Applications: WB, IHC
NBP1-05163
Species: Hu, Rt, Po, Bv
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
NB120-14817
Species: Hu, Rt
Applications: WB, ICC/IF, IHC, S-ELISA
NBP1-46535
Species: Hu, Mu, Rt, Rb, Xp, Ze
Applications: WB, IHC, IHC-Fr, IHC-P
AF1052
Species: Hu
Applications: WB, Flow, IHC, CyTOF-ready
NBP2-37447
Species: Hu
Applications: WB, ELISA, Flow, IHC, IHC-P, CyTOF-ready, IF
NBP1-19788
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC, IHC-P
NB300-201
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
MAB6700
Species: Hu
Applications: Flow, CyTOF-ready
NBP1-89993
Species: Hu
Applications: WB, IHC, IHC-P
NBP2-33903
Species: Hu
Applications: IHC, IHC-P
NB300-201
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
NBP2-62664
Species: Hu
Applications: IHC, IHC-P
NB100-1533
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P, PEP-ELISA
NB300-119
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P
AF1182
Species: Hu
Applications: WB, Flow, IHC, IP, CyTOF-ready, ELISA(Cap), ELISA(Det), ELISA(Sta)
NB300-109
Species: Hu, Mu, Rt, Dr, I, Ma
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P, ICC, IHC-FrFl
NB100-65219
Species: Hu, Mu
Applications: ICC/IF, IHC, IHC-Fr, IHC-P, IHC-WhMt
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Publications for Substance P Antibody (NB100-65219)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: IHC-Fr, IHC-WhMt.


Filter By Application
IHC-Fr
(1)
IHC-WhMt
(1)
All Applications
Filter By Species
Mouse
(1)
All Species

Review for Substance P Antibody (NB100-65219) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Other.

Reviews using NB100-65219:
Filter by Applications
IHC-Fr
(1)
All Applications
Filter by Species
Other
(1)
All Species
Images Ratings Applications Species Date Details
Immunohistochemistry-Frozen Substance P NB100-65219
Enlarge
reviewed by:
Giulia Di Cristina
IHC-Fr Other 07/21/2016
View

Summary

ApplicationImmunohistochemistry-Frozen
Sample TestedArm section
SpeciesOther
Lot080514

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

FAQs for Substance P Antibody (NB100-65219) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Array Products

Bioinformatics Tool for Substance P Antibody (NB100-65219)

Discover related pathways, diseases and genes to Substance P Antibody (NB100-65219). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Substance P Antibody (NB100-65219)

Discover more about diseases related to Substance P Antibody (NB100-65219).
 

Pathways for Substance P Antibody (NB100-65219)

View related products by pathway.

PTMs for Substance P Antibody (NB100-65219)

Learn more about PTMs related to Substance P Antibody (NB100-65219).
 

Research Areas for Substance P Antibody (NB100-65219)

Find related products by research area.

Blogs on Substance P

There are no specific blogs for Substance P, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Recent Reviews

4
5
0
4
1
3
0
2
0
1
0

Giulia Di Cristina
07/21/2016
Application: IHC-Fr
Species: Other

Bioinformatics

Gene Symbol TAC1
Entrez
Uniprot