Stathmin 1 [p Ser38] Antibody

Images

 
Western Blot: Stathmin 1 [p Ser38] Antibody [NBP1-51448] - analysis of p-Op18 (S38) pAb at 1:500 dilutionLane1:HEK293T cell lysate treated with colchicine(0.2ng/ml,24h)Lane2:Raw264.7 cell lysate treated with ...read more
Immunohistochemistry-Paraffin: Stathmin 1 [p Ser38] Antibody [NBP1-51448] - Human brain tissue.
Western Blot: Stathmin 1 [p Ser38] Antibody [NBP1-51448] - Extracts from HeLa nocodazole cells.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51448
    • Availability
      Product Discontinued

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Stathmin 1 [p Ser38] Antibody Summary

Immunogen
Synthetic phosphopeptide derived from human Op18 around the phosphorylation site of Serine 38.
Modification
p Ser38
Specificity
p-Op18 (S38) pAb detects endogenous levels of Op18 protein only when phosphorylated at S38.
Clonality
Polyclonal
Host
Rabbit
Gene
STMN1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analyzes of p-Op18 (S38) pAb in extracts from HeLa nocodazole cells.
Immunohistochemistry (IHC) analyzes of p-Op18 (S38) pAb in paraffin-embedded human brain tissue.
Theoretical MW
19 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Stathmin 1 [p Ser38] Antibody

  • C1orf215
  • chromosome 1 open reading frame 215
  • Lag
  • Leukemia-associated phosphoprotein p18
  • metablastin
  • MGC138869
  • Oncoprotein 18
  • Op18
  • OP18MGC138870
  • phosphoprotein 19
  • Phosphoprotein p19
  • PP17
  • PP19
  • PR22
  • prosolin
  • Protein Pr22
  • SMNLAP18FLJ32206
  • stathmin 1
  • stathmin 1/oncoprotein 18
  • stathmin
  • transmembrane protein C1orf215

Background

Oncoprotein 18 (Op18) is a regulator of microtubule (MT) dynamics. Op18 is a target for both cell cycle and cell surface receptor-coupled kinase systems, and phosphorylation of Op18 on specific combinations of amino acid residues has been shown to switch off MT-destabilizing activity of Op18. Induced expression of the catalytic subunit of cAMP-dependent protein kinase (PKA) results in a dramatic increase in cellular MT polymer content concomitant with phosphorylation and partial degradation of Op18. Phosphorylation of Op18 on two specific sites, Serine 16 and Serine 63, is necessary and sufficient for PKA to switch off Op18 activity in intact cells. PKA phosphorylation down-regulates the MT-destabilizing activity of Op18, which in turn promotes increased Tubulin polymerization. Op18 has the potential to regulate the MT system in response to external signals such as cAMP-linked agonists.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol STMN1