ST2/IL-1 R4 Antibody Summary
Antibody was raised against a synthetic peptide corresponding to 16 amino acids at the amino-terminus of mouse ST2. This peptide is common to all three known ST2 isoforms. The immunogen is located within amino acids 40 - 90 of ST2.
Immunogen affinity purified
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- Western Blot 1-2 ug/ml
- ELISA 1:100-1:2000
- Immunocytochemistry/Immunofluorescence 2 ug/mL
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Paraffin 2 ug/ml
ST2 antibody can be used for the detection of ST2 by Western blot at 1 to 2 mg/ml. Mouse kidney cell lysate can be used as positive control. Anti-ST2 is human and mouse reactive.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
Immunogen affinity purified
Alternate Names for ST2/IL-1 R4 Antibody
- IL-1 R4
- suppression of tumorigenicity 2
ST2 is a member of a superfamily containing the interleukin-1 receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. ST2 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF. More recently, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor (TLR) 4 signaling and to maintain endotoxin tolerance. It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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