Sphingosine Kinase 1/SPHK1 Antibody

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Immunohistochemistry-Paraffin: Sphingosine Kinase 1/SPHK1 Antibody [NB110-40448] - Analysis of anti-SPHK1 antibody with human adrenal, zona glomerulosa at concentration 20 ug/ml.

Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Sphingosine Kinase 1/SPHK1 Antibody Summary

Immunogen
Synthetic 15 amino acid peptide from N-terminus of human SPHK1.
Epitope
N-terminal domain of human
Specificity
This is specific to the human Sphingosine Kinase Type 1 protein.
Predicted Species
Primate (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SPHK1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 20 ug/ml

Reactivity Notes

Reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Sphingosine Kinase 1/SPHK1 Antibody

  • EC 2.7.1.91
  • SK1
  • sphingosine kinase 1
  • SPHK1
  • SPHKSK 1
  • SPK 1
  • SPK
  • SPK1

Background

Sphingosine kinase (SPHK) phosphorylates sphingosine to form a bioactive lipid mediate, sphingosine 1-phosphate (S1P or SPP). S1P is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival while extracellularly it is a ligand for EDG 1. Expression of SPHK1 and subsequent production of S1P promotes the G1-S transition, protects cells from apoptosis, stimulates migration and angiogenesis and induces tumor formation in mice.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SPHK1
Entrez