SOX1 Antibody [Unconjugated]

Western blot shows lysates of undifferentiated iBJ6 human iPS cells and iBJ6 human iPS cells differentiated into neuroprogenitor cells. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). A specific band was detected for SOX1 at approximately 39 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

SOX1 was detected in immersion fixed BG01V human embryonic stem cells differentiated into neural progenitor cells using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Nestin was also detected using Mouse Anti-Mouse/Rat Nestin Monoclonal Antibody (MAB2736) and stained using the NorthernLights™ 493-conjugated Anti-Mouse IgG Secondary Antibody (green; Catalog # NL009). Specific staining of SOX1 was localized to nuclei. View our protocol for Fluorescent ICC Staining of Stem Cells on Coverslips.

SOX1 was detected in immersion fixed NTera-2 human testicular embryonic carcinoma cell line differentiated with retinoic acid using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 493-conjugated Anti-Goat IgG Secondary Antibody (green, upper panel; NL003) and counterstained with DAPI (blue, lower panel). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

SOX1 was detected in immersion fixed rat cortical stem cells (NSC001) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

SOX1 was detected in immersion fixed mouse cortical stem cells (Catalog # NSC002) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

SOX1 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (VC001). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to nuclei in neuron. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Simple Western lane view shows lysates of undifferentiated iBJ6 human iPS cells andiBJ6 human iPS cells differentiated into neuroprogenitor cells, loaded at 0.2 mg/mL. A specific band was detected for SOX1 at approximately 50 kDa (as indicated) using 10 µg/mL of Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Characterization of NSCs and cortical neurons derived from FKRP‐ and CRISPR/Cas9 corrected‐iPSCsA, BRepresentative images of NSCs derived from FKRP‐ and corrected‐iPSC lines expressing SOX1, SOX2, and nestin.C, DQuantification of percentage of SOX1+ (C) and SOX2+ (D) cells in culture. The efficiency of neural induction is more than 99% in FKRP‐ and corrected‐iPSC (5D17, 5D23, and 3B17) lines. Data are mean ± s.d. n = 4 technical replicates.E, FFKRP‐ and corrected‐NSC lines can be further differentiated to cortical neural progenitor cells, expressing PAX6, OTX2, and vimentin.G–IQuantification of percentage of PAX6+ (G) and OTX2+ (H) cells in culture. About 91‐98% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express PAX6 (G). About 93‐96% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express OTX2 (H). Of the OTX2+ population, about 60‐67% cells are also Ki67+ cycling progenitors (I). Data are mean ± s.d. n = 4 technical replicates.J, KGlutamatergic projection neurons derived from FKRP and corrected (5D17, 5D23, and 3B17) progenitor cells. The vast majority of neurons contain vGlut1+ punctae in their neurites (labeled by Tuj1). Right panels are enlarged images from the insets of left panels.Data information: Scale bars, 50 μm. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31566294), licensed under a CC-BY license. Not internally tested by R&D Systems.

Characterization of NSCs and cortical neurons derived from FKRP‐ and CRISPR/Cas9 corrected‐iPSCsA, BRepresentative images of NSCs derived from FKRP‐ and corrected‐iPSC lines expressing SOX1, SOX2, and nestin.C, DQuantification of percentage of SOX1+ (C) and SOX2+ (D) cells in culture. The efficiency of neural induction is more than 99% in FKRP‐ and corrected‐iPSC (5D17, 5D23, and 3B17) lines. Data are mean ± s.d. n = 4 technical replicates.E, FFKRP‐ and corrected‐NSC lines can be further differentiated to cortical neural progenitor cells, expressing PAX6, OTX2, and vimentin.G–IQuantification of percentage of PAX6+ (G) and OTX2+ (H) cells in culture. About 91‐98% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express PAX6 (G). About 93‐96% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express OTX2 (H). Of the OTX2+ population, about 60‐67% cells are also Ki67+ cycling progenitors (I). Data are mean ± s.d. n = 4 technical replicates.J, KGlutamatergic projection neurons derived from FKRP and corrected (5D17, 5D23, and 3B17) progenitor cells. The vast majority of neurons contain vGlut1+ punctae in their neurites (labeled by Tuj1). Right panels are enlarged images from the insets of left panels.Data information: Scale bars, 50 μm. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31566294), licensed under a CC-BY license. Not internally tested by R&D Systems.

Expression of NSUN2 in the Human Developing Brain and NES Cells(A) DAPI-stained human embryo (6 weeks of gestation) marked for prosencephalon, mesencephalon, and rhombencephalon. Region in square is magnified in (B). Scale bar, 1 mm.(B) Prosencephalon labeled for NSUN2 and SOX1. Region in squares are magnified in (b′) and (b″). Arrows indicate NSUN2-positive cells. Scale bar, 100 μm.(C–F) Bright-field image (C) and immunofluorescence (D–F) of AF22 (upper panels) and Sai1 (lower panels) cells labeled for Nestin (D), SOX2 (E), and beta III-tubulin (F). Scale bar, 50 μm.(G and H) NES cells co-labeled for NSUN2 and Nestin (NES) (G) or SOX1 (H).(I) Differentiation protocol.(J–L) Differentiated AF22 and Sai1 cells (day 15) labeled for Nestin (NES; J), SOX2 (K), and beta III-tubulin (L). Scale bars: 50 μm.(M) Western blot for NSUN2, beta III-tubulin (TUBB3), GFAP, SOX2, and Nestin during differentiation (days). alpha -Tubulin served as loading control.Nuclei are counterstained with DAPI (A, B, D–F, J–L). Image collected and cropped by CiteAb from the following publication (//linkinghub.elsevier.com/retrieve/pii/S2213671116302764), licensed under a CC-BY license. Not internally tested by R&D Systems.

Expression of NSUN2 in the Human Developing Brain and NES Cells(A) DAPI-stained human embryo (6 weeks of gestation) marked for prosencephalon, mesencephalon, and rhombencephalon. Region in square is magnified in (B). Scale bar, 1 mm.(B) Prosencephalon labeled for NSUN2 and SOX1. Region in squares are magnified in (b′) and (b″). Arrows indicate NSUN2-positive cells. Scale bar, 100 μm.(C–F) Bright-field image (C) and immunofluorescence (D–F) of AF22 (upper panels) and Sai1 (lower panels) cells labeled for Nestin (D), SOX2 (E), and beta III-tubulin (F). Scale bar, 50 μm.(G and H) NES cells co-labeled for NSUN2 and Nestin (NES) (G) or SOX1 (H).(I) Differentiation protocol.(J–L) Differentiated AF22 and Sai1 cells (day 15) labeled for Nestin (NES; J), SOX2 (K), and beta III-tubulin (L). Scale bars: 50 μm.(M) Western blot for NSUN2, beta III-tubulin (TUBB3), GFAP, SOX2, and Nestin during differentiation (days). alpha -Tubulin served as loading control.Nuclei are counterstained with DAPI (A, B, D–F, J–L). Image collected and cropped by CiteAb from the following publication (//linkinghub.elsevier.com/retrieve/pii/S2213671116302764), licensed under a CC-BY license. Not internally tested by R&D Systems.

GPI anchored proteins are required for neural differentiation.(A). Representative example of images of hiPSC-derived EBs and EB-derived rosettes during neural differentiation. Neural induction and rosette formation upon neural induction was assessed in three cell lines using a serum-free EB generation method. On day 2 (left) of hiPSC-derived EBs from PIGAwt, PIGAc.1234C>T, and PIGAnull after forced aggregation (20X magnification, scale bar is 50μm). On day 4 (middle), single homogeneous hiPSC-EBs collected were pooled in a 10 cm plate (4X magnification, scale bar is 100μm). On day 11 (right), neuroepithelial cells appeared and neural tube-like rosettes formed (EB-derived rosettes) and scale bar is 50μm. (B). Neural induction rates from EB-derived rosettes. The percentage of EB derived rosettes was 88.8% ± 4.6, 75.5% ± 9.8 and 68.4% ± 6.9 for PIGAwt, PIGAc.1234C>T, and PIGAnull, respectively. PIGAwt versus PIGAc.1234C>T (p>0.05, NS) and PIGAwt versus PIGAnull (*pT compared to PIGAwt. (F). Graphs depict the percentage of positive cells for SOX-1 (left) and Pax6 (right) in hNPCs derived from PIGAwt, PIGAc.1234C>T, and PIGAnull hiPSC lines. The hNPCs derived from the PIGAnull hiPSCs showed significantly decreased expression of SOX1 and PAX6. Similar levels of SOX1 and PAX6 were expressed in hNPCs from PIGAwt and PIGAc.1234C>T. All values represent mean ± SD. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0174074), licensed under a CC-BY license. Not internally tested by R&D Systems.

Loss of DNMT3B impairs meso-endoderm lineage commitment. A Schematic representation of the two-step differentiation model from ESCs to EpiLCs first with Fgf beta & Activin A, & then to meso-endoderm (ME) progenitors with iGsk3. The time points of ’ collection are reported in the colour-code used throughout the figures (i.e., shades of grey for WT, shades of orange for 3BKO). b Hierarchical clustering of RNA-seq data from the in vitro differentiation & in vivo embryonic tissues derived from pre- & post-implantation mouse embryos35. Pearson’s correlation distance & Ward’s method employed to perform the analysis. c On the left, an RNA-seq heatmap showing the results of gene expression profiles clustering with K-means for WT & 3BKO (two independent clones) during the complete differentiation time course (ESC-EpiLC-ME). DEGs arising during the differentiation time course in any group identified by ANOVA-like test with edgeR54. Rows are genes, columns are samples & the scaled expression level (Z-score RPKM) is plotted. On the right, heatmap showing selected GO terms for enriched biological processes in each cluster. Terms related to meso-endoderm are highlighted in red. d Gene expression time-course for stage-specific pluripotency (naive, primed) & germ layers (mesoderm, endoderm, ectoderm) marker genes. Dots represent normalized RPKM values, averaged by replicates/conditions (n = 2 biological replicates per genotype or clone at each time point). Error bars represent standard errors. e, WB analysis of the de novo DNMTs (Dnmt3a1, Dnmt3a2, Dnmt3b), T (mesodermal marker) & Sox1 (neuro-ectodermal marker) expression during the differentiation time course. beta -actin serves as loading control. Representative of two independent experiments. Uncropped gels are provided in Supplementary Fig. 11. Image collected & cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/36690616), licensed under a CC-BY license. Not internally tested by R&D Systems.

Characterization of NS/PCs derived from hiPSCs. b, Representative images (b) of immunocytochemical analysis of hiPSC-NS/PCs (NS/PC-A & NS/PC-B) using antibodies against SOX1, SOX2, & NESTIN. Inset: Hoechst nuclear staining of the same field. Scale bar, 50 μm. Image collected & cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/37286713), licensed under a CC-BY license. Not internally tested by R&D Systems.

Loss of DNMT3B impairs meso-endoderm lineage commitment. A Schematic representation of the two-step differentiation model from ESCs to EpiLCs first with Fgf beta & Activin A, & then to meso-endoderm (ME) progenitors with iGsk3. The time points of ’ collection are reported in the colour-code used throughout the figures (i.e., shades of grey for WT, shades of orange for 3BKO). b Hierarchical clustering of RNA-seq data from the in vitro differentiation & in vivo embryonic tissues derived from pre- & post-implantation mouse embryos35. Pearson’s correlation distance & Ward’s method employed to perform the analysis. c On the left, an RNA-seq heatmap showing the results of gene expression profiles clustering with K-means for WT & 3BKO (two independent clones) during the complete differentiation time course (ESC-EpiLC-ME). DEGs arising during the differentiation time course in any group identified by ANOVA-like test with edgeR54. Rows are genes, columns are samples & the scaled expression level (Z-score RPKM) is plotted. On the right, heatmap showing selected GO terms for enriched biological processes in each cluster. Terms related to meso-endoderm are highlighted in red. d Gene expression time-course for stage-specific pluripotency (naive, primed) & germ layers (mesoderm, endoderm, ectoderm) marker genes. Dots represent normalized RPKM values, averaged by replicates/conditions (n = 2 biological replicates per genotype or clone at each time point). Error bars represent standard errors. e, WB analysis of the de novo DNMTs (Dnmt3a1, Dnmt3a2, Dnmt3b), T (mesodermal marker) & Sox1 (neuro-ectodermal marker) expression during the differentiation time course. beta -actin serves as loading control. Representative of two independent experiments. Uncropped gels are provided in Supplementary Fig. 11. Image collected & cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/36690616), licensed under a CC-BY license. Not internally tested by R&D Systems.

Characterization of NS/PCs derived from hiPSCs. b, Representative images (b) of immunocytochemical analysis of hiPSC-NS/PCs (NS/PC-A & NS/PC-B) using antibodies against SOX1, SOX2, & NESTIN. Inset: Hoechst nuclear staining of the same field. Scale bar, 50 μm. Image collected & cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/37286713), licensed under a CC-BY license. Not internally tested by R&D Systems.

• Reactivity: Hu, Mu, Rt
• Applications: WB, Simple Western, IHC, ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

SOX1 Antibody [Unconjugated] Summary

• Immunogen: E. coli-derived recombinant human SOX1
  Asn242-Gly379 (Leu276Ile)
  Accession # NP_005977
• Specificity: Detects human SOX1 in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: SOX1
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry 5-15 ug/mL
  • Immunohistochemistry 3-15 ug/mL
  • Simple Western 10 ug/mL
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SOX1 Antibody [Unconjugated]

• SOX1
• SRY (sex determining region Y)-box 1
• SRY-related HMG-box gene 1
• transcription factor SOX-1

Background

SOX1 is a 39 kDa transcription factor that belongs to the SOXB1 subgroup. Within the developing CNS, SOX1 maintains neural cells in an undifferentiated state and has been used as a marker for neural stem cells. Human and mouse SOX1 share 97% amino acid sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SOX1 Antibody (AF3369)(158)

Publications using AF3369

• Zuccaro, MV;Young, RE;Hu, J;Lanzano, P;Semenova, E;Lin, X;Skowronski, A;Shen, Y;Kim, TH;Miller, DE;Germain, N;Sarmiere, P;LeDuc, CA;Chung, WK; Antisense oligonucleotides to KIF1A polymorphisms expand targets and rescue patient-derived neurons in vitro Nature communications 2026-01-09 [PMID: 41513671] (Immunocytochemistry, Human)
• Lucero, K;Han, S;Huang, PY;Qiu, X;Mazzoni, EO;Reinberg, D; CTCF-RNA interactions orchestrate cell-specific chromatin loop organization Science advances 2025-11-28 [PMID: 41296854] (Flow Cytometry, Immunocytochemistry, Mouse)
• Pei, Y;Li, S;Garipler, G;Kamimoto, K;Mazzoni, EO; Stem cell-based approach to identify regulatory TFs during mammalian cell differentiation Stem cell reports 2025-11-20 [PMID: 41270744] (Immunocytochemistry, Mouse)
• Yi, S;Huang, M;Xian, C;Kong, X;Yin, S;Peng, J;Li, H;Jiang, Y;Xie, B;Xie, H; Hedgehog signaling activation rescues hypoxia-induced ferroptosis in human brain organoids Neural regeneration research 2025-09-29 [PMID: 41017694] (Immunohistochemistry, Human)
• Zheng, Y;Chen, X;Bu, P;Xue, H;Kim, DH;Zhou, H;Xia, X;Liu, Y;Cao, Q; Functional Recovery by Transplantation of Human iPSC-Derived A2B5 Positive Neural Progenitor Cell After Spinal Cord Injury in Mice International journal of molecular sciences 2025-09-13 [PMID: 41009511] (Immunohistochemistry, Mouse)
• Li, S;Zheng, Y;Xue, H;Zhang, H;Wu, J;Chen, X;Perez Bouza, M;Yi, S;Zhou, H;Xia, X;Zeng, X;Cao, QL;Liu, Y; Macrophage Migration Inhibitory Factor Suppresses Natural Killer Cell Response and Promotes Hypoimmunogenic Stem Cell Engraftment Following Spinal Cord Injury Biology 2025-06-30 [PMID: 40723350] (Immunohistochemistry, Transgenic Mouse)
• Li, S;Zheng, Y;Xue, H;Zhang, H;Wu, J;Chen, X;Bouza, MP;Yi, S;Zhou, H;Xia, X;Zeng, X;Cao, QL;Liu, Y; Macrophage Migration Inhibitory Factor Suppresses Natural Killer Cell Response and Promotes Hypoimmunogenic Stem Cell Engraftment Following Spinal Cord Injury bioRxiv : the preprint server for biology 2025-05-07 [PMID: 40655027] (Immunohistochemistry, Transgenic Mouse)
• Huang, Y;Chen, Z;Deng, W;Jiang, Y;Pan, Y;Yuan, Z;Hu, H;Wu, Y;Hu, Y; CHCHD2 rescues the mitochondrial dysfunction in iPSC-derived neurons from patient with Mohr-Tranebjaerg syndrome Cell death & disease 2025-03-12 [PMID: 40075073] (Immunocytochemistry, Human)
• Jeon, J;Cha, Y;Hong, YJ;Lee, IH;Jang, H;Ko, S;Naumenko, S;Kim, M;Ryu, HL;Shrestha, Z;Lee, N;Park, TY;Park, H;Kim, SH;Yoon, KJ;Song, B;Schweitzer, J;Herrington, TM;Kong, SW;Carter, B;Leblanc, P;Kim, KS; Pre-clinical safety and efficacy of human induced pluripotent stem cell-derived products for autologous cell therapy in Parkinson's disease Cell stem cell 2025-03-06 [PMID: 39952239] (Immunohistochemistry, Mouse)
• Huang, C;Qiu, L;Zhou, W;Shao, C;Wang, X;Zhang, Q;Chen, W;Xiong, M;Huang, M;Tang, M;Zou, L;Xu, X; A human-induced pluripotent stem cell (iPSC) line (SMUSHi006-A) from an ALS patient carrying a mutation c.1126C > T in the FUS gene Stem cell research 2024-11-09 [PMID: 39662462] (Immunocytochemistry, Human)
• Deng, YC;Liu, JW;Ting, HC;Kuo, TC;Chiang, CH;Lin, EY;Harn, HJ;Lin, SZ;Chang, CY;Chiou, TW; n-Butylidenephthalide recovered calcium homeostasis to ameliorate neurodegeneration of motor neurons derived from amyotrophic lateral sclerosis iPSCs PloS one 2024-11-07 [PMID: 39509425] (Immunocytochemistry, Human)
• McCreery, KP;Stubb, A;Stephens, R;Fursova, NA;Cook, A;Kruse, K;Michelbach, A;Biggs, LC;Keikhosravi, A;Nykänen, S;Hydén-Granskog, C;Zou, J;Lackmann, JW;Niessen, CM;Vuoristo, S;Miroshnikova, YA;Wickström, SA; Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells bioRxiv : the preprint server for biology 2024-09-07 [PMID: 39372762] (Immunohistochemistry, Immunocytochemistry, Human)
• Zhao, M;Wang, J;Liu, M;Xu, Y;Huang, J;Zhang, Y;He, J;Gu, A;Liu, M;Liu, X; KIF1A, R1457Q, and P1688L Mutations Induce Protein Abnormal Aggregation and Autophagy Impairment in iPSC-Derived Motor Neurons Biomedicines 2024-07-30 [PMID: 39200158] (Immunocytochemistry, Human)
• Tonin, R;Feo, F;Falliano, S;Giunti, L;Calamai, M;Procopio, E;Mari, F;Sciruicchio, V;Conti, V;Fanelli, I;Bambi, F;Guerrini, R;Morrone, A; Generation of a human induced pluripotent stem cell line from a patient with GM3 synthase deficiency using self-replicating RNA vector Stem cell research 2024-05-03 [PMID: 38703669] (Immunocytochemistry, Human)
• Kanemura, Y;Yamamoto, A;Katsuma, A;Fukusumi, H;Shofuda, T;Kanematsu, D;Handa, Y;Sumida, M;Yoshioka, E;Mine, Y;Yamaguchi, R;Okada, M;Igarashi, M;Sekino, Y;Shirao, T;Nakamura, M;Okano, H; Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Showed Neuronal Differentiation, Neurite Extension, and Formation of Synaptic Structures in Rodent Ischemic Stroke Brains Cells 2024-04-12 [PMID: 38667286] (Immunohistochemistry, Immunocytochemistry, Human, Xenograft)
• Szepanowski, L;Wruck, W;Kapr, J;Rossi, A;Fritsche, E;Krutmann, J;Adjaye, J; Cockayne Syndrome Patient iPSC-Derived Brain Organoids and Neurospheres Show Early Transcriptional Dysregulation of Biological Processes Associated with Brain Development and Metabolism Cells 2024-03-28 [PMID: 38607030] (Immunocytochemistry, Human)
• Sun, Z;Chen, Z;Yin, M;Wu, X;Guo, B;Cheng, X;Quan, R;Sun, Y;Zhang, Q;Fan, Y;Jin, C;Yin, Y;Hou, X;Liu, W;Shu, M;Xue, X;Shi, Y;Chen, B;Xiao, Z;Dai, J;Zhao, Y; Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids Cell stem cell 2024-03-26 [PMID: 38565140] (Immunohistochemistry, Rabbit, Rat)
• Werren, EA;LaForce, GR;Srivastava, A;Perillo, DR;Li, S;Johnson, K;Baris, S;Berger, B;Regan, SL;Pfennig, CD;de Munnik, S;Pfundt, R;Hebbar, M;Jimenez-Heredia, R;Karakoc-Aydiner, E;Ozen, A;Dmytrus, J;Krolo, A;Corning, K;Prijoles, EJ;Louie, RJ;Lebel, RR;Le, TL;Amiel, J;Gordon, CT;Boztug, K;Girisha, KM;Shukla, A;Bielas, SL;Schaffer, AE; TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome Nature communications 2024-02-22 [PMID: 38388531] (IHC, Human, Mouse)
• Capauto, D;Wang, Y;Wu, F;Norton, S;Mariani, J;Inoue, F;Crawford, GE;Ahituv, N;Abyzov, A;Vaccarino, FM; Characterization of enhancer activity in early human neurodevelopment using Massively Parallel Reporter Assay (MPRA) and forebrain organoids Scientific reports 2024-02-16 [PMID: 38365907] (Immunocytochemistry, Human)
• Bhatia, P;Bickle, M;Agrawal, A;Truss, B;Nikolaidi, A;Brockmann, K;Reinhardt, L;Vogel, S;Szegoe, E;Pal, A;Hermann, A;Miki?i?, I;Yun, M;Falkenburger, B;Sterneckert, J; Axonal Lysosomal Assays for Characterizing the Effects of LRRK2 G2019S Biology 2024-01-20 [PMID: 38275734] (Immunocytochemistry, Human)
• Liu, C;Xie, Y;Chen, X;Liu, L;Liu, C;Yin, Z; BAF45D-binding to HOX genes was differentially targeted in H9-derived spinal cord neural stem cells Scientific reports 2024-01-02 [PMID: 38168763] (ICC, Human)
• Tang, M;Xiong, M;Zhou, W;Lei, J;Huang, M;Huang, C;Wang, F;Liu, J;Li, J;Xu, X; Generation of a human induced pluripotent stem cell line (SMUSHi002-A) from an ALS patient carrying a heterozygous mutation c.1562G > A in the FUS gene Stem cell research 2023-12-16 [PMID: 38141357] (Flow Cytometry, Immunohistochemistry, Human)
• Park, S;Park, CW;Eom, JH;Jo, MY;Hur, HJ;Choi, SK;Lee, JS;Nam, ST;Jo, KS;Oh, YW;Lee, J;Kim, S;Kim, DH;Park, CY;Kim, SJ;Lee, HY;Cho, MS;Kim, DS;Kim, DW; Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease Cell stem cell 2023-12-07 [PMID: 38086390] (Immunocytochemistry, Human)
• Tao, Y;Li, X;Dong, Q;Kong, L;Petersen, AJ;Yan, Y;Xu, K;Zima, S;Li, Y;Schmidt, DK;Ayala, M;Mathivanan, S;Sousa, AMM;Chang, Q;Zhang, SC; Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells Nature biotechnology 2023-11-16 [PMID: 37974010] (Flow Cytometry, IHC, Mouse)
• Jaratsittisin, J;Sornjai, W;Chailangkarn, T;Jongkaewwattana, A;Smith, DR; The vitamin D receptor agonist EB1089 can exert its antiviral activity independently of the vitamin D receptor PloS one 2023-10-17 [PMID: 37847693] (ICC, Human)
• Oleksy, C;Massart, F;Goldwurm, S;Arado, A;Arena, G;Boussaad, I;Krüger, R; Generation and characterization of induced pluripotent stem cells from a Parkinson's disease patient carrying the digenic LRRK2 p.G2019S and GBA1 p.N409S mutations Stem cell research 2023-09-28 [PMID: 37832355] (ICC, Human)
• Fiock, KL;Hook, JN;Hefti, MM; Determinants of astrocytic pathology in stem cell models of primary tauopathies Acta neuropathologica communications 2023-10-06 [PMID: 37803326] (Bioassay, Human)
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Bioinformatics

• Gene Symbol: SOX1
• Uniprot:
  • NP_005977()