Sonic Hedgehog/Shh Antibody

Images

 
Immunohistochemistry-Paraffin: Sonic Hedgehog/Shh Antibody [NBP1-36497] - Human Lung

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Sonic Hedgehog/Shh Antibody Summary

Immunogen
A synthetic peptide corresponding to N-terminus of human Sonic Hedgehog
Specificity
This product is specific for Sonic Hedgehog
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SHH
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:100

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.6) and 1.0% BSA
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for Sonic Hedgehog/Shh Antibody

  • HHG1
  • HHG-1
  • HLP3
  • HPE3
  • MCOPCB5sonic hedgehog (Drosophila) homolog
  • Shh
  • SMMCIsonic hedgehog homolog (Drosophila)
  • sonic hedgehog homolog
  • sonic hedgehog protein
  • Sonic Hedgehog
  • TPT
  • TPTPS

Background

Sonic Hedgehog Protein (SHH, VHH-1) belongs to hedgehog protein family which includes Indian Hh, and Desert Hh. Hh family is involved in the cell fate and patterning during embryonic development, homeostasis, and adult tissue renewal (1). Similar to other member in the family, SHH binds to the patched (PTC) cell surface receptor, releasing the signal transducer Smoothened (Smo) to transmit the Hh signal into the cell and activate transcription of the target gene (2). Precursor SHH is autocatlytically cleaved into two subunits, N-terminal and C-terminal products. Soluble N-terminal product is involved in the signaling activity, while C-product displays an autoproteolysis activity on the precursor and a cholesterol transferase activity on the N-terminal product. C-terminal product attaches a cholesterol moiety to the N-terminal product, preventing N-terminal product diffusion within the developing embryo (3). A defect in SHH has been linked in holoprosencephaly type 3 (HPE3), in which developing forebrain fails to separate into right and left hemispheres, and ocular coloboma (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NB600-600
Species: Hu, Mu
Applications: WB, ChIP, ELISA, IHC, IHC-P, Flow-IC
NB200-118
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P
NBP1-57016
Species: Hu
Applications: WB
H00003077-M01
Species: Hu
Applications: WB, ELISA, ICC/IF
423-F8/CF
Species: Hu, Mu
NBP2-24543
Species: Hu, Mu, Pm
Applications: WB, IHC-P
NBP2-55775
Species: Hu
Applications: WB, ICC/IF
NBP2-24543
Species: Hu, Mu, Pm
Applications: WB, IHC-P
AF3690
Species: Hu, Mu
Applications: WB, ChIP, ICC
NBP2-23602
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC, IHC-Fr, IHC-P
1705-HH/CF
Species: Hu, Mu
355-BM/CF
Species: Hu, Mu, Rt
NBP1-33581
Species: Hu, Rt
Applications: ICC/IF, IHC, IHC-P
AF482
Species: Mu
Applications: WB, IHC
NBP1-85351
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
NBP2-33404
Species: Hu
Applications: IHC, IHC-P
NBP1-36497
Species: Hu
Applications: IHC, IHC-P

Publications for Sonic Hedgehog/Shh Antibody (NBP1-36497) (0)

There are no publications for Sonic Hedgehog/Shh Antibody (NBP1-36497).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Sonic Hedgehog/Shh Antibody (NBP1-36497) (0)

There are no reviews for Sonic Hedgehog/Shh Antibody (NBP1-36497). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for Sonic Hedgehog/Shh Antibody (NBP1-36497) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Sonic Hedgehog/Shh Products

Bioinformatics Tool for Sonic Hedgehog/Shh Antibody (NBP1-36497)

Discover related pathways, diseases and genes to Sonic Hedgehog/Shh Antibody (NBP1-36497). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Sonic Hedgehog/Shh Antibody (NBP1-36497)

Discover more about diseases related to Sonic Hedgehog/Shh Antibody (NBP1-36497).
 

Pathways for Sonic Hedgehog/Shh Antibody (NBP1-36497)

View related products by pathway.

PTMs for Sonic Hedgehog/Shh Antibody (NBP1-36497)

Learn more about PTMs related to Sonic Hedgehog/Shh Antibody (NBP1-36497).
 

Research Areas for Sonic Hedgehog/Shh Antibody (NBP1-36497)

Find related products by research area.

Blogs on Sonic Hedgehog/Shh

There are no specific blogs for Sonic Hedgehog/Shh, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Sonic Hedgehog/Shh Antibody and receive a gift card or discount.

Bioinformatics

Gene Symbol SHH
Entrez