SOCS-3 Antibody

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Western Blot: SOCS-3 Antibody [NB100-773] - (1ug/ml) staining of MOLT4 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Western Blot: SOCS-3 Antibody [NB100-773] - (5ug/ml) of MOLT-4 lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

SOCS-3 Antibody Summary

Immunogen
Peptide with sequence C-PIREFLDQYDAPL corresponding to C-Terminus according to NP_003946.3.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SOCS3
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 4-6 ug/ml
  • Peptide ELISA Detection limit 1:16000
Application Notes
WB: Approx. 24 kDa band observed in MOLT-4 lysate.
Positive Control
SOCS-3 Lysate (NBL1-16327)
Publications
Read Publication using NB100-773.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine, Porcine, Bovine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SOCS-3 Antibody

  • ATOD4
  • CIS3
  • CIS3CIS-3
  • Cish3
  • cytokine-induced SH2 protein 3
  • Cytokine-inducible SH2 protein 3
  • SOCS3
  • SOCS-3
  • SOCS-3STAT-induced STAT inhibitor 3
  • SSI-3
  • SSI-3ATOD4
  • SSI3MGC71791
  • suppressor of cytokine signaling 3

Background

Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family that have been recognized, they are SOCS 1 - 7 and CIS. Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain and a previously unrecognized C-terminal motif that has been called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo, in response to cytokines. Once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 3 is an important regulator of fetal liverhematopoiesis. It is also involved in a broad spectrum of cytokines, e.g. IL2, IL3, IL4, IL6, Epo, Prolactin, and GH. Recent findings suggest that aberrant induction of SOCS3 by pathogens, such as Leishmania donovani and hepatitis C virus, might interfere with the host immune response and contribute to the persistent infection by these pathogens.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SOCS-3 Antibody (NB100-773)(1)

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Video Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol SOCS3
Entrez
Uniprot