SOCS-2 Antibody

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Western Blot: SOCS-2 Antibody [NBP1-51218] - Extracts from Jurkat cells

Product Details

Summary
Product Discontinued
View other related SOCS-2 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-51218
    • Availability
      Product Discontinued

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SOCS-2 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 41-90 of Human SOCS-2.
Specificity
SOCS-2 (E67) pAb detects endogenous levels of SOCS-2 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
SOCS2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
Application Notes
Western blot (WB) analysis of SOCS-2 (E67) pAb in extracts from Jurkat cells
Theoretical MW
22 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Cross reacts with Human, Mouse and Rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SOCS-2 Antibody

  • CIS2
  • CIS2CIS-2
  • Cish2
  • Cytokine-inducible SH2 protein 2
  • SOCS2
  • SOCS-2
  • SOCS-2STAT-induced STAT inhibitor 2
  • SSI2
  • SSI-2STAT induced STAT inhibitor-2
  • SSI2STAT-induced STAT inhibitor-2
  • STATI2
  • STATI2suppressor of cytokine signaling-2
  • suppressor of cytokine signaling 2

Background

SOCS2 is capable of inhibiting cytokine signalling by interleukin-6 (IL-6) and growth hormone. SOCS2 interacts with the phosphorylated insulin-like growth factor (IGF-I) receptor, where it may play a regulatory role in cellular growth, differentiation, and inhibition of apoptosis via the Ras and PI3K signalling pathways. In humans, SOCS2 mRNA is expressed widely in both foetal and adult tissues, including foetal kidney and adult heart, skeletal muscle, pancreas, and liver. In rats, SOCS2 mRNA exhibits high levels of expression in liver and heart, and in the mouse nervous system, SOCS2 is expressed exclusively by neurons, where it is switched on developmentally in concordance with neuronal differentiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SOCS2
Entrez