SMN Antibody

Images

 
Western Blot: SMN Antibody [NBP1-03325] - Detection of Human SMN1 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-03325
    • Availability
      Product Discontinued

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SMN Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 50 and 100 of human survival of motor neuron 1 using the numbering given in entry NP_000335.1 (GeneID 6606).
Clonality
Polyclonal
Host
Rabbit
Gene
SMN1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunoprecipitation 1:10-1:500
Application Notes
This antibody is not recommended for Western Blot analysis.
Positive Control
SMN Lysate (NBL1-16243)

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SMN Antibody

  • Gemin-1
  • Kugelberg-Welander disease)
  • SMNC
  • survival of motor neuron 1, telomeric

Background

Gemin 1 (SMN) is the central component of a large oligomeric complex (SMN complex), including Gemins 2-7, that is necessary and sufficient for the in vivo assembly of Sm proteins onto the small nuclear (sn)RNAs that mediate pre-mRNA splicing. The SMN complex is found in the cytoplasm and nucleus. Within the nucleus, this protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). Spinal muscular atrophy, a motor neuron disorder, results from reduced levels or a mutation in the Gemin 1 protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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FAQs for SMN Antibody (NBP1-03325). (Showing 1 - 1 of 1 FAQ).

  1. Could you recommond the Human specific SMN antibody? It will only recognize human SMN, without cross reaction with mouse smn.
    • We do not have an SMN antibody that has been validated NOT to work in mouse samples. When an antibody is found to not react with a certain species, we mark the data sheet with a (-) next to the species' name. Unfortunately, the SMN antibodies that do not list mouse have not been tested in mouse, and may react.

Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Additional SMN Products

SMN NBP1-03325

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Diseases for SMN Antibody (NBP1-03325)

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PTMs for SMN Antibody (NBP1-03325)

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Bioinformatics

Gene Symbol SMN1
Entrez
Uniprot