SMAC/Diablo Antibody (79-1-83)

Images

 
Western Blot: Smac/DIABLO Antibody [NBP1-19193] - Lane 1: MW marker, Lane 2: 293, Lane 3: HeLa, Lane 4: Jurkat, Lane 5: Vero

Product Details

Summary
Product Discontinued
View other related SMAC/Diablo Primary Antibodies

Order Details


    • Catalog Number
      NBP1-19193
    • Availability
      Product Discontinued

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SMAC/Diablo Antibody (79-1-83) Summary

Immunogen
Recombinant full length human Smac/DIABLO
Specificity
Smac/DIABLO (79-1-83)
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
DIABLO
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000

Reactivity Notes

Human, Monkey.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
No buffer
Preservative
Sodium Azide
Purity
Protein G purified

Alternate Names for SMAC/Diablo Antibody (79-1-83)

  • 0610041G12Rik
  • Diablo
  • diablo, IAP-binding mitochondrial protein
  • Direct IAP-binding protein with low pI
  • mitochondrial Smac protein
  • Second mitochondria-derived activator of caspase
  • SMAC
  • SMACmitochondrial

Background

Smac/DIABLO is one of the pro-apoptotic proteins normally found in the intermembrane space of the mitochondria. In response to apoptotic stimuli, Smac/DIABLO is released into the cytosol resulting in permeabilization of the mitochondrial membrane. Cytosolic Smac/DIABLO activates caspase-9 by binding IAP proteins. Changes in the expression level of Smac/DIABLO have been demonstrated in a number of human cancers including melanoma, ovary, and prostate.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Additional SMAC/Diablo Products

Bioinformatics Tool for SMAC/Diablo Antibody (NBP1-19193)

Discover related pathways, diseases and genes to SMAC/Diablo Antibody (NBP1-19193). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for SMAC/Diablo Antibody (NBP1-19193)

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Pathways for SMAC/Diablo Antibody (NBP1-19193)

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PTMs for SMAC/Diablo Antibody (NBP1-19193)

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Blogs on SMAC/Diablo.

Apoptosis and Necroptosis Part II: Inhibitors of apoptosis proteins (IAPs); Key regulators of the balance between necroptosis, apoptosis and survival
In the first installment of this two-part blog post titled "Apoptosis and Necroptosis: Important factors to identify both types of programmed cell death", the mechanisms by which cell death occurs and ways to identify these pathways were...  Read full blog post.

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Bioinformatics

Gene Symbol DIABLO
Entrez