Siglec-3/CD33 Antibody (CD33-4D3) [PE]

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Product Details

Summary
Product Discontinued
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    • Catalog Number
      NBP1-42498
    • Availability
      Product Discontinued

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Siglec-3/CD33 Antibody (CD33-4D3) [PE] Summary

Immunogen
The antibody reacts with the CD33 antigen.
Specificity
The monoclonal antibody reacts with human CD33. The CD33 antigen is expressed on monocytes, myeloid progenitor cells and mast cells.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CD33
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
Application Notes
The antibody can be used for flow cytometry. The main cellular reactivities are monocytes and myeloid progenitor cells. F/P Ratio: 1.This antibody has been titred for application in flow cytometry. 5 µl is the maximum amount of reagent required for 1 x 106 cells. Lesser amounts of antibody may be sufficient and it is recommended that the customer determines the optimum amount of antibody for each applica­tion. See further instructions for use A.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
High grade BSA
Preservative
Sodium Azide
Purity
Protein A or G purified

Alternate Names for Siglec-3/CD33 Antibody (CD33-4D3) [PE]

  • CD33 antigen (gp67)
  • CD33 antigen
  • CD33 molecule
  • CD33
  • FLJ00391
  • gp67
  • myeloid cell surface antigen CD33
  • p67
  • sialic acid binding Ig-like lectin 3
  • Sialic acid-binding Ig-like lectin 3
  • Siglec3
  • Siglec-3
  • SIGLEC3gp67

Background

CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CD33
Entrez