Siglec-2/CD22 Antibody (Bu59) [FITC]

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-63587
    • Availability
      Product Discontinued

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Siglec-2/CD22 Antibody (Bu59) [FITC] Summary

Immunogen
Made to Human CD22
Specificity
NB100-63586 recognizes human CD22, a 130/140kD cell surface glycoprotein which is expressed by cells of B-lymphocyte lineage. CD22 is differentially expressed during B cell maturation. Initially, CD22 is expressed in the cytoplasm of pro-B and pre-B cells and then on the cell surface of mature B cells. CD22 expression is lost upon terminal differentiation to plasma cells. CD22 functions as an adhesion receptor, for leucocytes and erythrocytes, and a signalling molecule which may play a role in B-cell activation.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CD22
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000

Reactivity Notes

Reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4) and 1.0% BSA
Preservative
0.09% Sodium Azide
Concentration
0.1 mg/ml
Purity
Protein G purified

Alternate Names for Siglec-2/CD22 Antibody (Bu59) [FITC]

  • B-cell receptor CD22
  • BL-CAM
  • B-lymphocyte cell adhesion molecule
  • CD22 antigenMGC130020
  • CD22 molecule
  • CD22
  • sialic acid binding Ig-like lectin 2
  • Sialic acid-binding Ig-like lectin 2
  • Siglec2
  • Siglec-2
  • SIGLEC2FLJ22814
  • T-cell surface antigen Leu-14

Background

CD22 is a type 1 integral membrane glycoprotein with molecular weight of 130 to 140kD. It is expressed in both the cytoplasm and cell membrane of B lymphocytes. CD22 antigen appears early in B cell lymphocyte differentiation at approximately the same stage as the CD19 antigen. Unlike other B cell markers, CD22 membrane expression is limited to the late differentiation stages comprised between mature B cells (CD22+) and plasma cells (CD22-), and may thus prove useful in phenotyping mature leukemias. CD22 is also strongly expressed in hairy cell leukemia. There are two different isoforms of CD22. It exists predominantly as a monomer of the beta isoform but can also be found as a heterodimer composed of the beta isoform and a second, shorter isoform (CD22 alpha).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for Siglec-2/CD22 Antibody (NB100-63587). (Showing 1 - 1 of 1 FAQ).

  1. I am interested in buying a CD22 antibody for fluorescence microscopy and FACS I red on your web page that you also offer to label your antibodies, if required, is that correct?
    • We do have the ability to perform custom conjugations on certain antibodies, including some to the CD22 protein. If you send me the conjugate you are interested in I can provide you with a quote.

Secondary Antibodies

 

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PTMs for Siglec-2/CD22 Antibody (NB100-63587)

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Bioinformatics

Gene Symbol CD22
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