Siglec-2/CD22 Antibody (2D6) [Biotin]

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-27904
    • Availability
      Product Discontinued

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Siglec-2/CD22 Antibody (2D6) [Biotin] Summary

Immunogen
Splenic lymphocyte plasma membranes from CBA x C57 F1 mice
Specificity
CD22 (Mr 150 kDa), a B lymphocyte adhesion molecule
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Rat
Gene
CD22
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry <= 1 ug/10^6 cells
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunoprecipitation 1:10-1:500
  • Immunocytochemistry
Readout System

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Protect conjugated forms from light.

Alternate Names for Siglec-2/CD22 Antibody (2D6) [Biotin]

  • B-cell receptor CD22
  • BL-CAM
  • B-lymphocyte cell adhesion molecule
  • CD22 antigenMGC130020
  • CD22 molecule
  • CD22
  • sialic acid binding Ig-like lectin 2
  • Sialic acid-binding Ig-like lectin 2
  • Siglec2
  • Siglec-2
  • SIGLEC2FLJ22814
  • T-cell surface antigen Leu-14

Background

CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. (1, 2) CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. (2-4) Its intracellular domain is phosphorylated after antigen receptor cross linking and is involved in negative regulation of B-cell activation. (6-9)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for Siglec-2/CD22 Antibody (NBP1-27904). (Showing 1 - 1 of 1 FAQ).

  1. I am interested in buying a CD22 antibody for fluorescence microscopy and FACS I red on your web page that you also offer to label your antibodies, if required, is that correct?
    • We do have the ability to perform custom conjugations on certain antibodies, including some to the CD22 protein. If you send me the conjugate you are interested in I can provide you with a quote.

Secondary Antibodies

 

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Bioinformatics

Gene Symbol CD22
Entrez