SHP-2/PTPN11 Antibody - Pre-diluted

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Immunohistochemistry-Paraffin: SHP-2/PTPN11 Antibody - Pre-diluted [NBP1-36472] - Human Bone Marrow stained with anti-SH-PTP2 antibody.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-36472
    • Availability
      Product Discontinued

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SHP-2/PTPN11 Antibody - Pre-diluted Summary

Immunogen
Synthetic peptide corresponding to aa 576-593 of human SH-PTP2 protein.
Specificity
This product is specific for SH-PTP2
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PTPN11
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin Neat

Reactivity Notes

Predicted by homology: Chicken, Frog, Mouse, Porcine, Rabbit, Rat.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Prediluted antibody
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for SHP-2/PTPN11 Antibody - Pre-diluted

  • BPTP3
  • EC 3.1.3.48
  • MGC14433
  • protein tyrosine phosphatase, non-receptor type 11
  • protein tyrosine phosphatase-2
  • Protein-tyrosine phosphatase 1D
  • Protein-tyrosine phosphatase 2C
  • PTP1D
  • PTP-1D
  • PTP2C
  • PTP-2C
  • PTP2CNS1
  • PTPN11
  • SHP2
  • SHP-2
  • SHP2CFC
  • SHPTP2
  • SH-PTP2
  • SH-PTP2Noonan syndrome 1
  • SH-PTP3
  • tyrosine-protein phosphatase non-receptor type 11

Background

SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in t the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Over expression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Additional SHP-2/PTPN11 Products

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Diseases for SHP-2/PTPN11 Antibody (NBP1-36472)

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Bioinformatics

Gene Symbol PTPN11
Entrez