SHP-2/PTPN11 [p Tyr542] Antibody


Western Blot: PTPN11/SHP2 [phospho Tyr542] Antibody [NB100-92627] - SH-PTP2 (Y580) pAb in A549 cells.
Immunohistochemistry-Paraffin: PTPN11/SHP2 [phospho Tyr542] Antibody [NB100-92627] Human brain tissue.
Western Blot: PTPN11/SHP2 [phospho Tyr542] Antibody [NB100-92627] - Western blot (WB) analysis of p-SHP-2 (Y542) antibody in extracts from A431 or HuvEc cells.

Product Details

Product Discontinued
View other related SHP-2/PTPN11 Primary Antibodies

Order Details

    • Catalog Number
    • Availability
      Product Discontinued

    Can't find what you are looking for? Use our Antibody Concierge Service & we will help you locate your antibody!

    Or feel free to contact us for alternative products.

SHP-2/PTPN11 [p Tyr542] Antibody Summary

Synthetic phosphopeptide derived from human SHP-2 around the phosphorylation site of Tyrosine 542.
p Tyr542
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of p-SH-PTP2 (Y580) pAb in A549 cells.
Immunohistochemistry (IHC) analyzes of p-SH-PTP2 (Y580) pAb in paraffin-embedded human brain tissue.
Theoretical MW
70 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Mouse and Rat.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.2)
0.05% Sodium Azide
1.0 mg/ml
Immunogen affinity purified

Alternate Names for SHP-2/PTPN11 [p Tyr542] Antibody

  • BPTP3
  • EC
  • MGC14433
  • protein tyrosine phosphatase, non-receptor type 11
  • protein tyrosine phosphatase-2
  • Protein-tyrosine phosphatase 1D
  • Protein-tyrosine phosphatase 2C
  • PTP1D
  • PTP-1D
  • PTP2C
  • PTP-2C
  • PTP2CNS1
  • PTPN11
  • SHP2
  • SHP-2
  • SHPTP2
  • SH-PTP2
  • SH-PTP2Noonan syndrome 1
  • SH-PTP3
  • tyrosine-protein phosphatase non-receptor type 11


SHP (also designated short heterodimer partner and small heterodimer partner) is an orphan nuclear receptor containing the dimerization and ligandbinding domains found in other nuclear receptors but lacking the conserved DNA binding domain. SHP is specifically expressed in liver and other tissues including fetal liver and adrenal gland, adult spleen and small intestine. In addition, SHP is highy expressed in the murine macrophage cell line RAW 264.7 but suppressed by oxLDL and 13-HODE, which is a ligand for PPARgamma. SHP interacts with nuclear receptors including thyroid receptor, retinoic acid receptors (RAR and RXR) and estrogen receptors (ERa and ERb). SHP functions as a negative regulator of these receptors by at least three mechanisms: inhibition of DNA binding via dimerization, direct antagonism of coactivator function via competition and possibly transrepression via recruitment of putative corepressors. In oxLDL-treated, resting macrophage cells, SHP acts as a transcription coactivator of NF-kappaB, suggesting that SHP is a modulatory component in the regulation of the transcriptional activities of NF-kappaB. Lastly, negative feedback regulation of a hepatic bile acid transporter NTCP is controlled by bile acid-activated FXR via induction of SHP to protect the hepatocyte from bile acid-mediated damage in cholestatic conditions.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Rt, Hu(-)
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, Simple Western, IHC
Species: Hu
Applications: WB, ELISA, ICC/IF, IP
Species: Hu, Mu, Rt, Mk
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC
Species: Hu, Mu, Rt, Po
Applications: WB, IHC, IHC-P, PEP-ELISA
Species: Hu, Mu
Applications: WB, Simple Western, Flow, IHC, CyTOF-ready, ICC
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, IP
Species: Hu
Applications: WB, Flow, CyTOF-ready, ICC
Species: Hu, Mu, Rt
Applications: WB, IHC
Species: Hu, Mu, Rt
Applications: WB, IHC
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, CyTOF-ready, ICFlow
Species: Hu
Applications: WB, IHC, IHC-P
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP, Flow-IC
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P

Publications for SHP-2/PTPN11 Antibody (NB100-92627) (0)

There are no publications for SHP-2/PTPN11 Antibody (NB100-92627).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for SHP-2/PTPN11 Antibody (NB100-92627) (0)

There are no reviews for SHP-2/PTPN11 Antibody (NB100-92627). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for SHP-2/PTPN11 Antibody (NB100-92627) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Additional SHP-2/PTPN11 Products

Bioinformatics Tool for SHP-2/PTPN11 Antibody (NB100-92627)

Discover related pathways, diseases and genes to SHP-2/PTPN11 Antibody (NB100-92627). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for SHP-2/PTPN11 Antibody (NB100-92627)

Discover more about diseases related to SHP-2/PTPN11 Antibody (NB100-92627).

Pathways for SHP-2/PTPN11 Antibody (NB100-92627)

View related products by pathway.

PTMs for SHP-2/PTPN11 Antibody (NB100-92627)

Learn more about PTMs related to SHP-2/PTPN11 Antibody (NB100-92627).

Blogs on SHP-2/PTPN11

There are no specific blogs for SHP-2/PTPN11, but you can read our latest blog posts.

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our SHP-2/PTPN11 [p Tyr542] Antibody and receive a gift card or discount.


Gene Symbol PTPN11