SHP-2/PTPN11 Antibody (2F4)

Images

 
Western Blot: PTPN11/SHP2 Antibody (2F4) [NBP2-03064] HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTPN11/SHP2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell ...read more
Flow Cytometry: PTPN11/SHP2 Antibody (2F4) [NBP2-03064] - Analysis of Jurkat cells, using anti-PTPN11/SHP2 antibody, (Red), compared to a nonspecific negative control antibody (Blue).
Flow Cytometry: PTPN11/SHP2 Antibody (2F4) [NBP2-03064] - Analysis of Hela cells, using anti-PTPN11/SHP2 antibody, (Red), compared to a nonspecific negative control antibody (Blue).

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP2-03064
    • Availability
      Product Discontinued

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SHP-2/PTPN11 Antibody (2F4) Summary

Immunogen
Full length human recombinant protein of human PTPN11(NP_002825) produced in HEK293T cell.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
PTPN11
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Flow Cytometry 1:100

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for SHP-2/PTPN11 Antibody (2F4)

  • BPTP3
  • EC 3.1.3.48
  • MGC14433
  • protein tyrosine phosphatase, non-receptor type 11
  • protein tyrosine phosphatase-2
  • Protein-tyrosine phosphatase 1D
  • Protein-tyrosine phosphatase 2C
  • PTP1D
  • PTP-1D
  • PTP2C
  • PTP-2C
  • PTP2CNS1
  • PTPN11
  • SHP2
  • SHP-2
  • SHP2CFC
  • SHPTP2
  • SH-PTP2
  • SH-PTP2Noonan syndrome 1
  • SH-PTP3
  • tyrosine-protein phosphatase non-receptor type 11

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq].

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional SHP-2/PTPN11 Products

Bioinformatics Tool for PTPN11/SHP2 Antibody (NBP2-03064)

Discover related pathways, diseases and genes to PTPN11/SHP2 Antibody (NBP2-03064). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for PTPN11/SHP2 Antibody (NBP2-03064)

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Pathways for PTPN11/SHP2 Antibody (NBP2-03064)

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PTMs for PTPN11/SHP2 Antibody (NBP2-03064)

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Research Areas for PTPN11/SHP2 Antibody (NBP2-03064)

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Bioinformatics

Gene Symbol PTPN11
Entrez