SHC1 Antibody


Western Blot: SHC1 Antibody [NB100-92055] - Analysis of SHC1 Antibody in extracts from HeLa cells treated with Calyculin A 50nM 15' or HeLa cells treated with Calyculin A 100nM 30'.
Immunohistochemistry: SHC1 Antibody [NB100-92055] - Analyzes of SHC1 Antibody in paraffin-embedded human brain colon carcinoma tissue.

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SHC1 Antibody Summary

Synthetic peptide, corresponding to amino acids 390-440 of Human Shc.
SHC1 (L421) detects endogenous levels of Shc protein.
Immunogen affinity purified
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  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of SHC1 (L421) pAb in extracts from HeLa cells treated with Calyculin A 50nM 15' or HeLa cells treated with Calyculin A 100nM 30'.
Immunohistochemistry (IHC) analyzes of SHC1 (L421) pAb in paraffin-embedded human brain colon
Theoretical MW
46 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Positive Control
SHC1 Lysate (NBP2-65828)

Reactivity Notes

This antibody is reactive against Human.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.2)
0.05% Sodium Azide
1.0 mg/ml
Immunogen affinity purified

Alternate Names for SHC1 Antibody

  • FLJ26504
  • p66
  • p66SHC
  • SH2 domain protein C1
  • SHC (Src homology 2 domain containing) transforming protein 1
  • SHC (Src homology 2 domain-containing) transforming protein 1
  • SHC
  • SHC1
  • SHCA
  • SHC-transforming protein 1
  • SHC-transforming protein 3
  • SHC-transforming protein A
  • Src homology 2 domain-containing-transforming protein C1


Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus activating mitogenic, as well as other, responses. Critical components of this process include adapter proteins such as SHC1 and IRS-1 that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to physically link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major insulin receptor substrate. Shc also participates in insulin signaling by linking the insulin receptor to Ras by forming complexes with the adapter protein GRB2 and Sos independently of IRS-1. A protein immunologically related to IRS-1, originally designated 4PS and now known as IRS-2, was shown to become highly tyrosine phosphorylated in response to IL-4 or IGF-1 in cells lacking IRS-1. An additional member of this family of signaling intermediates, Shb, is a SH2-containing protein with characteristic proline-rich domains.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

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Gene Symbol SHC1